Molecular structure of Mycophenolic acid-d3, CAS Number: 1185242-90-3
Mycophenolic acid-d3 (CAS 1185242-90-3)
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Alternate Names:
(4E)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-d3-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid
Application:
Mycophenolic acid-d3 is a selective lymphocyte proliferation inhibitor
CAS Number:
1185242-90-3
Molecular Weight:
323.36
Molecular Formula:
C17H17D3O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Mycophenolic Acid-d3 is a deuterium-labeled analogue of mycophenolic acid, used in scientific research to study the chemical kinetics and metabolic pathways of mycophenolic acid by employing mass spectrometry. This labeling with deuterium allows for a minimal yet distinguishable mass difference, making Mycophenolic Acid-d3 an ideal internal standard. By incorporating this compound in experiments, researchers can achieve more accurate quantification and tracking of mycophenolic acid in biological matrices. Additionally, the use of Mycophenolic Acid-d3 facilitates the exploration of the mechanisms by which mycophenolic acid interacts with specific molecular targets, such as inosine monophosphate dehydrogenase (IMPDH), which is involved in purine biosynthesis. The compound is also valuable in the study of its impact on the immune system at the cellular level, particularly on lymphocyte proliferation.
Mycophenolic acid-d3 (CAS 1185242-90-3) References
- Pharmacodynamics of immunosuppression by mycophenolic acid: inhibition of both lymphocyte proliferation and activation correlates with pharmacokinetics. | Gummert, JF., et al. 1999. J Pharmacol Exp Ther. 291: 1100-12. PMID: 10565830
- Sample cleanup-free determination of mycophenolic acid and its glucuronide in serum and plasma using the novel technology of ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry. | Kuhn, J., et al. 2010. Talanta. 80: 1894-8. PMID: 20152429
- Two rapid ultra performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) methods with common sample pretreatment for therapeutic drug monitoring of immunosuppressants compared to immunoassay. | Tszyrsznic, W., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 928: 9-15. PMID: 23584041
- Identifying the differences in mechanisms of mycophenolic acid controlling fucose content of glycoproteins expressed in different CHO cell lines. | Zhang, A., et al. 2016. Biotechnol Bioeng. 113: 2367-76. PMID: 27093551
- Determination of mycophenolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry. | Upadhyay, V., et al. 2014. J Pharm Anal. 4: 205-216. PMID: 29403884
- Comparison of PETINIA and LC-MS/MS for determining plasma mycophenolic acid concentrations in Japanese lung transplant recipients. | Kikuchi, M., et al. 2018. J Pharm Health Care Sci. 4: 7. PMID: 29619240
- Effect of pterostilbene on in vitro drug metabolizing enzyme activity. | Albassam, AA. and Frye, RF. 2019. Saudi Pharm J. 27: 406-412. PMID: 30976185
- Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug-drug interactions. | Qin, Z., et al. 2020. Chin Med. 15: 69. PMID: 32655683
- DETECTION OF GLIOTOXIN BUT NOT BIS(METHYL)GLIOTOXIN IN PLASMA FROM BIRDS WITH CONFIRMED AND PROBABLE ASPERGILLOSIS. | Reidy, L., et al. 2022. J Zoo Wildl Med. 53: 60-69. PMID: 35339150
- Noncompartmental pharmacokinetics of three intravenous mycophenolate mofetil concentrations in healthy Standardbred mares. | Burroughs, DL., et al. 2022. Vet Dermatol.. PMID: 35929548
- Application of a new volumetric microsampling device for quantitative bioanalysis of immunosuppression. | Leino, AD., et al. 2022. Bioanalysis. 14: 1141-1152. PMID: 36208082
- Multi-target analysis of cytostatics in hospital effluents over a 9-month period. | Gouveia, TIA., et al. 2023. J Hazard Mater. 448: 130883. PMID: 36731320
- Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. | Senda, M., et al. 1995. Transplantation. 60: 1143-8. PMID: 7482723
- Conformational changes and stabilization of inosine 5'-monophosphate dehydrogenase associated with ligand binding and inhibition by mycophenolic acid. | Nimmesgern, E., et al. 1996. J Biol Chem. 271: 19421-7. PMID: 8702630
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mycophenolic acid-d3, 1 mg | sc-218896 | 1 mg | $669.00 |