Molecular structure of Mycophenolic acid β-D-glucuronide, CAS Number: 31528-44-6
Mycophenolic acid β-D-glucuronide (CAS 31528-44-6)
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Alternate Names:
Mycophenolic acid β-D-glucuronide also known as Mycophenolic Acid Glucosiduronate; Mycophenolic Acid Glucuronide; MPAG
Application:
Mycophenolic acid β-D-glucuronide is an inhibitor of lymphocyte proliferation via selective IMPDH inhibition
CAS Number:
31528-44-6
Purity:
≥96%
Molecular Weight:
496.46
Molecular Formula:
C23H28O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mycophenolic Acid β-D-Glucuronide is a metabolite of mycophenolic acid, formed through the process of glucuronidation, a major pathway for chemical metabolism in the liver. This compound is a significant subject of study in chemical kinetics, as it represents an important route of biotransformation for mycophenolic acid, which is utilized in various research applications. In the field of toxicology, Mycophenolic Acid β-D-Glucuronide is used to investigate the safety profile of mycophenolic acid by examining its elimination and potential accumulation in biological systems. Researchers also use this metabolite to explore the interactions of mycophenolic acid with glucuronidation enzymes, such as UDP-glucuronosyltransferases. Studies involving Mycophenolic Acid β-D-Glucuronide are critical for understanding the excretion of mycophenolic acid, as the glucuronide conjugate is often excreted in the urine.
Mycophenolic acid β-D-glucuronide (CAS 31528-44-6) References
- Pharmacodynamics of immunosuppression by mycophenolic acid: inhibition of both lymphocyte proliferation and activation correlates with pharmacokinetics. | Gummert, JF., et al. 1999. J Pharmacol Exp Ther. 291: 1100-12. PMID: 10565830
- Determination of mycophenolic acid glucuronide in microsomal incubations using high performance liquid chromatography-tandem mass spectrometry. | Mohamed, MF., et al. 2008. J Chromatogr B Analyt Technol Biomed Life Sci. 870: 251-4. PMID: 18602350
- Screening of six UGT enzyme activities in human liver microsomes using liquid chromatography/triple quadrupole mass spectrometry. | Joo, J., et al. 2014. Rapid Commun Mass Spectrom. 28: 2405-14. PMID: 25303469
- AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5'-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes. | Kim, JH., et al. 2017. Molecules. 22: PMID: 28287454
- Inhibition of cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferases by MAM-2201 in human liver microsomes. | Kong, TY., et al. 2017. Arch Pharm Res. 40: 727-735. PMID: 28484907
- Sensitive Rapid Fluorescence Polarization Immunoassay for Free Mycophenolic Acid Determination in Human Serum and Plasma. | Glahn-Martínez, B., et al. 2018. Anal Chem. 90: 5459-5465. PMID: 29579378
- In Vitro Inhibitory Effects of Synthetic Cannabinoid EAM-2201 on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes. | Kong, TY., et al. 2018. Molecules. 23: PMID: 29659506
- Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5'-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes. | Choi, WG., et al. 2020. Pharmaceutics. 12: PMID: 32131538
- MRP4 is responsible for the efflux transport of mycophenolic acid β-d glucuronide (MPAG) from hepatocytes to blood. | Berthier, J., et al. 2021. Xenobiotica. 51: 105-114. PMID: 32820679
- Pharmacokinetics of α-amanitin in mice using liquid chromatography-high resolution mass spectrometry and in vitro drug-drug interaction potentials. | Park, R., et al. 2021. J Toxicol Environ Health A. 84: 821-835. PMID: 34187333
- Inhibition of cytochrome P450 enzymes and uridine 5'-diphospho-glucuronosyltransferases by vicagrel in human liver microsomes: A prediction of potential drug-drug interactions. | Liu, S., et al. 2022. Chem Biol Interact. 352: 109775. PMID: 34910929
- Toxicokinetics of β-Amanitin in Mice and In Vitro Drug-Drug Interaction Potential. | Bang, YY., et al. 2022. Pharmaceutics. 14: PMID: 35456608
- Synthesis of mycophenolic acid beta-D-glucuronide and its antitumor activity. | Ando, K., et al. 1970. J Antibiot (Tokyo). 23: 408-13. PMID: 5453317
- Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. | Senda, M., et al. 1995. Transplantation. 60: 1143-8. PMID: 7482723
- Conformational changes and stabilization of inosine 5'-monophosphate dehydrogenase associated with ligand binding and inhibition by mycophenolic acid. | Nimmesgern, E., et al. 1996. J Biol Chem. 271: 19421-7. PMID: 8702630
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mycophenolic acid β-D-glucuronide, 2.5 mg | sc-207897 | 2.5 mg | $374.00 | |||
Mycophenolic acid β-D-glucuronide, 5 mg | sc-207897A | 5 mg | $666.00 | |||
Mycophenolic acid β-D-glucuronide, 10 mg | sc-207897B | 10 mg | $1141.00 | |||
Mycophenolic acid β-D-glucuronide, 25 mg | sc-207897C | 25 mg | $2651.00 | |||
Mycophenolic acid β-D-glucuronide, 50 mg | sc-207897D | 50 mg | $4029.00 |