Date published: 2025-12-18

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Mycobacterium tuberculosis TB43 Antibody (1C3): sc-80487

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  • Mycobacterium tuberculosis TB43 Antibody (1C3) is a mouse monoclonal IgG1 Mycobacterium tuberculosis TB43 antibody provided at 100 µg/ml
  • raised against TB43 of Mycobacterium tuberculosis origin
  • recommended for detection of TB43 of Mycobacterium tuberculosis origin by WB
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mycobacterium tuberculosis TB43 Antibody (1C3). This work is in progress.

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    Mycobacterium tuberculosis TB43 Antibody (1C3) is a mouse monoclonal IgG1 antibody that detects the Mycobacterium tuberculosis TB43 protein of Mycobacterium tuberculosis origin by western blotting (WB). Mycobacterium tuberculosis TB43 (1C3) antibody is available as a non-conjugated format. Mycobacterium tuberculosis is the leading cause of tuberculosis and poses a significant threat to global health as one of the most dangerous human pathogens. This bacterium is a Gram-positive, obligate anaerobe that replicates slowly, with a division time of approximately 16 to 20 hours, and can only thrive within a host organism, often remaining dormant for extended periods without manifesting any symptoms. When active, Mycobacterium tuberculosis infection can lead to severe symptoms such as a chronic cough with blood, night sweats, fever, weight loss, chest pain, and extreme fatigue. The Mycobacterium tuberculosis bacterium is equipped with various auxiliary proteins that enhance virulence and overall functionality, including Mycobacterium tuberculosis TB43. Mycobacterium tuberculosis TB43 functions as a cell-associated pyridine nucleotide transhydrogenase, playing a crucial role in the regeneration of NADPH, which is essential for amino acid synthesis. The ability of Mycobacterium tuberculosis TB43 to facilitate this metabolic process is vital for bacterial survival and pathogenicity, making Mycobacterium tuberculosis TB43 an important target for research and therapeutic interventions.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    Mycobacterium tuberculosis TB43 Antibody (1C3) References:

    1. Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin.  |  Sherman, DR., et al. 2001. Proc Natl Acad Sci U S A. 98: 7534-9. PMID: 11416222
    2. Identification and characterization of mycobacterial proteins differentially expressed under standing and shaking culture conditions, including Rv2623 from a novel class of putative ATP-binding proteins.  |  Florczyk, MA., et al. 2001. Infect Immun. 69: 5777-85. PMID: 11500455
    3. Mycobacterium bovis BCG response regulator essential for hypoxic dormancy.  |  Boon, C. and Dick, T. 2002. J Bacteriol. 184: 6760-7. PMID: 12446625
    4. Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence.  |  Shi, L., et al. 2003. Proc Natl Acad Sci U S A. 100: 241-6. PMID: 12506197
    5. Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis.  |  Parish, T., et al. 2003. Infect Immun. 71: 1134-40. PMID: 12595424
    6. Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program.  |  Voskuil, MI., et al. 2003. J Exp Med. 198: 705-13. PMID: 12953092
    7. Koch's bacillus - a look at the first isolate of Mycobacterium tuberculosis from a modern perspective.  |  Taylor, GM., et al. 2003. Microbiology (Reading). 149: 3213-3220. PMID: 14600233
    8. Mycobacterium tuberculosis: ecology and evolution of a human bacterium.  |  Bañuls, AL., et al. 2015. J Med Microbiol. 64: 1261-1269. PMID: 26385049
    9. Targeting Mycobacterium tuberculosis pH-driven adaptation.  |  Dechow, SJ. and Abramovitch, RB. 2024. Microbiology (Reading). 170: PMID: 38717801
    10. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.  |  Cole, ST., et al. 1998. Nature. 393: 537-44. PMID: 9634230

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    Mycobacterium tuberculosis TB43 Antibody (1C3)

    sc-80487
    100 µg/ml
    $316.00