Myclobutanil (CAS 88671-89-0)
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Myclobutanil is a triazole antifungal agent known for its ability to inhibit ergosterol biosynthesis, a component of fungal cell membranes. This broad-spectrum systemic fungicide acts as a potent inhibitor, making it effective in preventing fungal attacks on plants. It is particularly efficient against powdery mildew in vegetables and cereals. Not only does Myclobutanil serve as a fungicide, but it has also been found to induce cytochrome P450 enzymes. In addition to its agricultural uses, Myclobutanil has been identified as a contaminant in concentrated Cannabis extracts from the California medical Cannabis market. As such, it has become a subject of research and forensic applications. Chemically, Myclobutanil is a light yellow solid and belongs to the triazole class of compounds. Its structure consists of 2-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile—a nitrile with a hexanenitrile backbone substituted at the 2-position by p-chlorophenyl and (1,2,4-triazol-1-yl)methyl groups.
Myclobutanil (CAS 88671-89-0) References
- Residue analysis and degradation studies of fenbuconazole and myclobutanil in strawberry by chiral high-performance liquid chromatography-tandem mass spectrometry. | Zhang, H., et al. 2011. J Agric Food Chem. 59: 12012-7. PMID: 21967215
- Dissipation and residues of myclobutanil in tobacco and soil under field conditions. | Wang, X., et al. 2012. Bull Environ Contam Toxicol. 88: 759-63. PMID: 22415649
- Effects of myclobutanil on soil microbial biomass, respiration, and soil nitrogen transformations. | Ju, C., et al. 2016. Environ Pollut. 208: 811-20. PMID: 26590854
- Myclobutanil worsens nonalcoholic fatty liver disease: An in vitro study of toxicity and apoptosis on HepG2 cells. | Stellavato, A., et al. 2016. Toxicol Lett. 262: 100-104. PMID: 27693777
- Tissue distribution and toxicity effects of myclobutanil enantiomers in lizards (Eremias argus). | Chen, L., et al. 2017. Ecotoxicol Environ Saf. 145: 623-629. PMID: 28806564
- Enantioselective degradation of Myclobutanil and Famoxadone in grape. | Lin, C., et al. 2018. Environ Sci Pollut Res Int. 25: 2718-2725. PMID: 29134531
- Selective effect of myclobutanil enantiomers on fungicidal activity and fumonisin production by Fusarium verticillioides under different environmental conditions. | Li, N., et al. 2018. Pestic Biochem Physiol. 147: 102-109. PMID: 29933978
- Acute toxicity and sublethal effects of myclobutanil on respiration, flight and detoxification enzymes in Apis cerana cerana. | Han, W., et al. 2018. Pestic Biochem Physiol. 147: 133-138. PMID: 29933983
- Myclobutanil accumulation, transcriptional alteration, and tissue injury in lizards (Eremias argus) treated with myclobutanil enantiomers. | Hao, W., et al. 2019. Ecotoxicol Environ Saf. 171: 247-255. PMID: 30612012
- Myclobutanil enantioselective risk assessment in humans through in vitro CYP450 reactions: Metabolism and inhibition studies. | Fonseca, FS., et al. 2019. Food Chem Toxicol. 128: 202-211. PMID: 30991128
- Cross-resistance between myclobutanil and tebuconazole and the genetic basis of tebuconazole resistance in Venturia inaequalis. | Cordero-Limon, L., et al. 2021. Pest Manag Sci. 77: 844-850. PMID: 32926586
- A multiplex lateral flow immunochromatography assay for the quantitative detection of pyraclostrobin, myclobutanil, and kresoxim-methyl residues in wheat. | Lin, L., et al. 2022. Food Chem. 377: 131964. PMID: 34999457
- Myclobutanil-mediated alteration of liver-gut FXR signaling in mice. | Taylor, R., et al. 2023. Toxicol Sci. 191: 387-399. PMID: 36511616
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Myclobutanil, 5 g | sc-205759 | 5 g | $117.00 | |||
Myclobutanil, 10 g | sc-205759A | 10 g | $204.00 |