Molecular structure of Mycalolide B, CAS Number: 122752-21-0
Mycalolide B (CAS 122752-21-0)
See product citations (4)
Alternate Names:
4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C
Application:
Mycalolide B is a novel and specific actomyosin ATPase inhibitor
CAS Number:
122752-21-0
Purity:
≥98%
Molecular Weight:
1027.16
Molecular Formula:
C52H74N4O17
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mycalolide B may act to inhibit actin polymerization (IC50=10-50 nM) with a different mechanism of action from cytochalasin D. It suppresses actin-activated myosin Mg2+-ATPase activity without changing myosin light chain phosphorylation resulting in inhibition of smooth muscle contractions. Mycalolide B depolymerizes F-actin at differing concentrations by nibbling and forms a 1:1 complex with G-actin. Mycalolide B, at a concentration of 3 muM, abolished both ADP (10 muM)- and collagen (3 mug/ml)-induced platelet aggregation in vitro.
Mycalolide B (CAS 122752-21-0) References
- Disruption of circumferential actin filament causes disappearance of occludin from the cell borders of rat hepatocytes in primary culture without distinct changes of tight junction strands. | Kojima, T., et al. 1999. Cell Struct Funct. 24: 11-7. PMID: 10355874
- Assessment of the marine toxins by monitoring the integrity of human intestinal Caco-2 cell monolayers. | Okada, T., et al. 2000. Toxicol In Vitro. 14: 219-26. PMID: 10806372
- Uncoupling of gate and fence functions of MDCK cells by the actin-depolymerizing reagent mycalolide B. | Takakuwa, R., et al. 2000. Exp Cell Res. 257: 238-44. PMID: 10837137
- Occludin regulates actin cytoskeleton in endothelial cells. | Kuwabara, H., et al. 2001. Cell Struct Funct. 26: 109-16. PMID: 11482453
- Actin filaments play an essential role for transport of nascent HIV-1 proteins in host cells. | Sasaki, H., et al. 2004. Biochem Biophys Res Commun. 316: 588-93. PMID: 15020258
- The SPR signal in living cells reflects changes other than the area of adhesion and the formation of cell constructions. | Yanase, Y., et al. 2007. Biosens Bioelectron. 22: 1081-6. PMID: 16621506
- The obligatory role of the actin cytoskeleton on inward remodeling induced by dithiothreitol activation of endogenous transglutaminase in isolated arterioles. | Castorena-Gonzalez, JA., et al. 2014. Am J Physiol Heart Circ Physiol. 306: H485-95. PMID: 24337457
- Mycalolide B dissociates dynactin and abolishes retrograde axonal transport of dense-core vesicles. | Cavolo, SL., et al. 2015. Mol Biol Cell. 26: 2664-72. PMID: 26023088
- Mycalolide B, a novel actin depolymerizing agent. | Saito, S., et al. 1994. J Biol Chem. 269: 29710-4. PMID: 7961961
- Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge. | Hori, M., et al. 1993. FEBS Lett. 322: 151-4. PMID: 8482383
- Cellular changes of rat embryonic fibroblasts by an actin-polymerization inhibitor, bistheonellide A, from a marine sponge. | Watabe, S., et al. 1996. Cell Struct Funct. 21: 199-212. PMID: 8853557
- Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D. | Sugidachi, A., et al. 1998. Thromb Haemost. 79: 614-9. PMID: 9531051
- Actin-binding specificity of marine macrolide toxins, mycalolide B and kabiramide D. | Wada, S., et al. 1998. J Biochem. 123: 946-52. PMID: 9562630
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mycalolide B, 20 µg | sc-358736 | 20 µg | $426.00 | |||
Mycalolide B, 100 µg | sc-358736A | 100 µg | $2091.00 |