Mxi1 Antibody (MXI1C2a): sc-130627

Mxi1 Antibody (MXI1C2a) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mxi1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Mxi1 antibody (MXI1C2a) is available as a non-conjugated format, providing researchers with a reliable tool for studying regulatory mechanisms of cell proliferation and differentiation. Mxi1 protein, also known as Mad 2, plays a crucial role in gene expression regulation by acting as a transcriptional repressor through forming heterodimers with Max protein, essential for Myc oncogene function. Mxi1 (MXI1C2a) antibody recognizes nuclear-localized Mxi1, where transcriptional activity regulation influences cellular processes like growth, differentiation, and apoptosis. Max stability, contrasting with short half-lives of Myc and Mxi1, allows for consistent regulatory framework, ensuring balance between proliferation and repression. Understanding Mxi1 dynamics and interactions helps elucidate pathways in cancer development and progression, making anti-Mxi1 antibody (MXI1C2a) valuable for research applications.

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Mxi1 Antibody (MXI1C2a) References:

1. Myc and Max proteins possess distinct transcriptional activities.  |  Kretzner, L., et al. 1992. Nature. 359: 426-9. PMID: 1406956
2. Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants.  |  Mukherjee, B., et al. 1992. Genes Dev. 6: 1480-92. PMID: 1644290
3. Loss of heterozygosity and microsatellite instability on chromosome arm 10q in neuroblastoma.  |  Lázcoz, P., et al. 2007. Cancer Genet Cytogenet. 174: 1-8. PMID: 17350460
4. Inactivation of Mxi1 induces Il-8 secretion activation in polycystic kidney.  |  Yoo, KH., et al. 2007. Biochem Biophys Res Commun. 356: 85-90. PMID: 17350592
5. N-Myc differentially regulates expression of MXI1 isoforms in neuroblastoma.  |  Armstrong, MB., et al. 2013. Neoplasia. 15: 1363-70. PMID: 24403858
6. Arginine methyltransferase PRMT5 methylates and destabilizes Mxi1 to confer radioresistance in non-small cell lung cancer.  |  Yang, X., et al. 2022. Cancer Lett. 532: 215594. PMID: 35149174
7. Mxi1 participates in the progression of lung cancer via the microRNA-300/KLF9/GADD34 Axis.  |  Lei, Y., et al. 2022. Cell Death Dis. 13: 425. PMID: 35501353
8. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.  |  Ayer, DE., et al. 1995. Cell. 80: 767-76. PMID: 7889570
9. An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3.  |  Schreiber-Agus, N., et al. 1995. Cell. 80: 777-86. PMID: 7889571
10. The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.  |  Amati, B., et al. 1993. EMBO J. 12: 5083-7. PMID: 8262051
11. Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity.  |  Ayer, DE., et al. 1993. Cell. 72: 211-22. PMID: 8425218
12. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.  |  Hurlin, PJ., et al. 1995. EMBO J. 14: 5646-59. PMID: 8521822

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mxi1 Antibody (MXI1C2a) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Mxi1 Antibody (MXI1C2a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mxi1 Antibody (MXI1C2a) Specifications

Alternate Product Name: Mxi1

Product Clone Name: MXI1C2a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Mxi1

Epitope Species: human

Product Reactivity/Detection: Mxi1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Mxi1 Antibody (MXI1C2a): N/A