MVK Antibody (D-3): sc-390669
- MVK Antibody (D-3) is a mouse monoclonal IgG1 κ MVK antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 97-396 mapping at the C-terminus of MVK of human origin
- MVK Antibody (D-3) is recommended for detection of MVK of human origin by WB, IP, IF and ELISA
- Anti-MVK Antibody (D-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MVK Antibody (D-3) for WB applications. These reagents are now offered in bundles with MVK Antibody (D-3) (see ordering information below).
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MVK Antibody (D-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects MVK protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MVK (D-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mevalonate kinase (MVK) plays a crucial role as an early enzyme in the biosynthesis of isoprenoids and sterols, catalyzing the ATP-dependent phosphorylation of mevalonic acid to produce mevalonate 5-phosphate. This reaction is vital because mevalonate serves as a key intermediate in the synthesis of cholesterol and other essential biomolecules, which are critical for cellular membrane integrity and signaling pathways. Deficiencies in MVK activity can lead to serious metabolic disorders, such as mevalonic aciduria and hyperimmunoglobulinemia D/periodic fever syndrome (HIDS), where the accumulation of mevalonic acid occurs due to the impaired conversion to 5-phosphomevalonic acid. The significance of MVK in these metabolic pathways underscores MVK (D-3) antibody′s potential in research and clinical applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MVK Antibody (D-3) References:
- Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome. | Houten, SM., et al. 1999. Nat Genet. 22: 175-7. PMID: 10369261
- Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome. | Houten, SM., et al. 2001. Eur J Hum Genet. 9: 253-9. PMID: 11313768
- Molecular analysis of MVK mutations and enzymatic activity in hyper-IgD and periodic fever syndrome. | Cuisset, L., et al. 2001. Eur J Hum Genet. 9: 260-6. PMID: 11313769
- The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. | Fu, Z., et al. 2002. J Biol Chem. 277: 18134-42. PMID: 11877411
- Carrier frequency of the V377I (1129G>A) MVK mutation, associated with Hyper-IgD and periodic fever syndrome, in the Netherlands. | Houten, SM., et al. 2003. Eur J Hum Genet. 11: 196-200. PMID: 12634869
- Molecular analysis of the MVK and TNFRSF1A genes in patients with a clinical presentation typical of the hyperimmunoglobulinemia D with periodic fever syndrome: a low-penetrance TNFRSF1A variant in a heterozygous MVK carrier possibly influences the phenotype of hyperimmunoglobulinemia D with periodic fever syndrome or vice versa. | Stojanov, S., et al. 2004. Arthritis Rheum. 50: 1951-8. PMID: 15188372
- On the MVK stochastic carcinogenesis model with Erlang distributed cell life lengths. | Zheng, Q. 1995. Risk Anal. 15: 495-502. PMID: 7480949
- On the exact hazard and survival functions of the MVK stochastic carcinogenesis model. | Zheng, Q. 1994. Risk Anal. 14: 1081-4. PMID: 7846316
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MVK Antibody (D-3) | sc-390669 | 200 µg/ml | $316.00 | |||
MVK Antibody (D-3): m-IgG Fc BP-HRP Bundle | sc-530220 | 200 µg Ab; 10 µg BP | $354.00 | |||
MVK Antibody (D-3): m-IgGκ BP-HRP Bundle | sc-523629 | 200 µg Ab, 40 µg BP | $354.00 | |||
MVK Antibody (D-3): m-IgG1 BP-HRP Bundle | sc-543937 | 200 µg Ab; 20 µg BP | $354.00 | |||
MVK Antibody (D-3) AC | sc-390669 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MVK Antibody (D-3) HRP | sc-390669 HRP | 200 µg/ml | $316.00 | |||
MVK Antibody (D-3) FITC | sc-390669 FITC | 200 µg/ml | $330.00 | |||
MVK Antibody (D-3) PE | sc-390669 PE | 200 µg/ml | $343.00 | |||
MVK Antibody (D-3) Alexa Fluor® 488 | sc-390669 AF488 | 200 µg/ml | $357.00 | |||
MVK Antibody (D-3) Alexa Fluor® 546 | sc-390669 AF546 | 200 µg/ml | $357.00 | |||
MVK Antibody (D-3) Alexa Fluor® 594 | sc-390669 AF594 | 200 µg/ml | $357.00 | |||
MVK Antibody (D-3) Alexa Fluor® 647 | sc-390669 AF647 | 200 µg/ml | $357.00 | |||
MVK Antibody (D-3) Alexa Fluor® 680 | sc-390669 AF680 | 200 µg/ml | $357.00 | |||
MVK Antibody (D-3) Alexa Fluor® 790 | sc-390669 AF790 | 200 µg/ml | $357.00 |