Mv 1 Lu + TGF Cell Lysate: sc-24737

Mv 1 Lu + TGF cell lysate is derived from Mv 1 Lu cells, a mink lung epithelial cell line, treated with transforming growth factor-beta (TGF-β). This lysate is extensively used in research to study the TGF-β signaling pathway and its role in cellular processes such as epithelial-mesenchymal transition (EMT), cell differentiation, and proliferation. TGF-β binds to its receptors, activating Smad-dependent and Smad-independent pathways, which are crucial for regulating gene expression and cellular responses. Researchers utilize Mv 1 Lu + TGF cell lysate to investigate the activation and interactions of key signaling molecules such as Smad2/3, which translocate to the nucleus to modulate transcription. This lysate facilitates the study of protein phosphorylation, expression levels, and post-translational modifications associated with TGF-β signaling. Additionally, it is used to analyze the cross-talk between TGF-β and other signaling pathways, including MAPK/ERK and PI3K/Akt, which influence cell growth and survival. Recent studies have leveraged this lysate for proteomic and genomic analyses to identify novel target genes and regulatory networks involved in TGF-β-induced EMT and other cellular processes. By providing insights into the molecular mechanisms of TGF-β signaling, Mv 1 Lu + TGF cell lysate remains a critical resource for advancing research in cell biology and signaling pathways.