Molecular structure of Muscone, CAS Number: 541-91-3
Muscone (CAS 541-91-3)
See product citations (2)
Alternate Names:
3-Methylcyclopentadecanone; Musk ketone
Application:
Muscone is a potent antiinflammatory agent, cytrochrome P-450 inducer, and apoptosis inhibitor
CAS Number:
541-91-3
Purity:
≥98%
Molecular Weight:
238.4
Molecular Formula:
C16H30O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Muscone is shown to reverse IL-1beta-induced upregulation of IL-1beta, TNFalpha, NOS2 (inducible nitric oxide synthase), Cox-2, aggrecanase 2, matrix metalloproteinase, and nitric oxide. In rat liver, muscone may act to induce CYP4F3 (cytochrome P-450) and to inhibit glutamate-induced apoptosis in PC-12 cells via maintenance of mitochondral membrane potential and inhibition of intracellular Ca2+ overload. Additional studies have reported muscone to be weakly estrogenically active in vitro. Muscone, also referred to as muskone, is an aromatic compound. Researchers study how muscone interacts with biological systems, such as receptors or enzymes, to understand its effects at a molecular level.
Muscone (CAS 541-91-3) References
- Estrogenic activity of musk fragrances detected by the E-screen assay using human mcf-7 cells. | Bitsch, N., et al. 2002. Arch Environ Contam Toxicol. 43: 257-64. PMID: 12202919
- Characterization of allegedly musk-containing medicinal products in Taiwan. | Lin, DL., et al. 2004. J Forensic Sci. 49: 1187-93. PMID: 15568689
- Synthesis of l-muscone by asymmetric methylation via enol esters. | Matsuda, H., et al. 2008. Chem Biodivers. 5: 1023-33. PMID: 18618396
- Muscone protects vertebral end-plate degeneration by antiinflammatory property. | Liang, QQ., et al. 2010. Clin Orthop Relat Res. 468: 1600-10. PMID: 19763723
- [Protective effects and machanism of muskone on pheochromocytoma cell injure induced by glutamate]. | Sun, R., et al. 2009. Zhongguo Zhong Yao Za Zhi. 34: 1701-4. PMID: 19873786
- Characterization of liver microsomal cytochrome P450 from rats treated with muscone (3-methylcyclopentadecanone). | Tanaka, E., et al. 1991. Biochem Pharmacol. 41: 472-3. PMID: 1994906
- Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells. | Phung, HM., et al. 2020. Biomolecules. 10: PMID: 33076219
- Muscone alleviates myocardial ischemia-reperfusion injury via inhibition of oxidative stress and enhancement of SIRT3. | Wei, CJ., et al. 2021. J Biol Regul Homeost Agents. 35: 85-96. PMID: 33480219
- Muscone suppresses gastric cancer via regulation of miRNA-145. | Gao, F., et al. 2021. Food Sci Nutr. 9: 4711-4721. PMID: 34531985
- Muscone Inhibits the Excessive Inflammatory Response in Myocardial Infarction by Targeting TREM-1. | Zhang, H., et al. 2022. Evid Based Complement Alternat Med. 2022: 9112479. PMID: 35591864
- Muscone improves hypoxia/reoxygenation (H/R)-induced neuronal injury by blocking HMGB1/TLR4/NF-κB pathway via modulating microRNA-142. | Ren, W., et al. 2022. PeerJ. 10: e13523. PMID: 35860039
- Muscone and (+)-Borneol Cooperatively Strengthen CREB Induction of Claudin 5 in IL-1β-Induced Endothelium Injury. | Li, YC., et al. 2022. Antioxidants (Basel). 11: PMID: 35892657
- Muscone suppresses myocardial ischemia damage by regulating PI3K/Akt signaling pathway. | Zhu, LL., et al. 2022. Biochim Biophys Acta Mol Basis Dis. 1868: 166539. PMID: 36100155
- Muscone with Attenuation of Neuroinflammation and Oxidative Stress Exerts Antidepressant-Like Effect in Mouse Model of Chronic Restraint Stress. | Liu, H., et al. 2022. Oxid Med Cell Longev. 2022: 3322535. PMID: 36211814
Inhibitor of:
Apoptosis.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Muscone, 100 mg | sc-200528 | 100 mg | $77.00 | |||
Muscone, 500 mg | sc-200528A | 500 mg | $250.00 |