Muscle Actin Antibody (4i346): sc-71625
- Muscle Actin Antibody (4i346) is a mouse monoclonal IgG1, cited in 1 publications, provided at 200 µg/ml
- raised against myocardium of human origin
- recommended for detection of muscle specific α and γ Actin isomers of mouse, rat and human origin by WB, IP, IF and IHC(P); non cross-reactive with beta Actin isomers
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Muscle Actin Antibody (4i346). This work is in progress.
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Muscle Actin Antibody (4i346) is a mouse monoclonal IgG2b antibody that detects Muscle Actin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Muscle Actin antibody (4i346) plays a crucial role in understanding the dynamics of the actin cytoskeleton, which is essential for various cellular functions, including maintaining cell shape, enabling motility, and facilitating intracellular transport. Muscle Actin exists in multiple isoforms, with α-Actin primarily found in muscle tissues, while β-Actin and γ-Actin are prevalent in non-muscle cells. The organization of the actin cytoskeleton is tightly regulated by small GTPases, which are critical for processes such as cell division and migration. For instance, Rho GTPase promotes the formation of stress fibers and focal adhesions, while Rac and Cdc42 are involved in the formation of lamellipodia and filopodia, respectively. Understanding the interactions and regulatory mechanisms of Muscle Actin is vital for elucidating the underlying processes of muscle contraction and cellular movement, making Muscle Actin monoclonal antibody (4i346) an invaluable tool for researchers studying muscle biology and related pathologies.
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Muscle Actin Antibody (4i346) References:
- Musculoskeletal connective tissue cells with muscle: expression of muscle actin in and contraction of fibroblasts, chondrocytes, and osteoblasts. | Spector, M. 2001. Wound Repair Regen. 9: 11-8. PMID: 11350635
- Alpha-smooth muscle actin expression in cultured cardiac fibroblasts of newborn rat. | Brouty-Boye, D., et al. 1992. In Vitro Cell Dev Biol. 28A: 293-6. PMID: 1583007
- Expression and function of alpha-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation. | Clément, S., et al. 2007. J Cell Sci. 120: 229-38. PMID: 17179203
- Muscle actin is polyubiquitinylated in vitro and in vivo and targeted for breakdown by the E3 ligase MuRF1. | Polge, C., et al. 2011. FASEB J. 25: 3790-802. PMID: 21764995
- Transcription of muscle actin genes by a nuclear form of mitochondrial RNA polymerase. | Lee, YL., et al. 2011. PLoS One. 6: e22583. PMID: 21799907
- Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection. | Alarcon-Martinez, L., et al. 2018. Elife. 7: PMID: 29561727
- Immunohistochemical study of alpha-smooth muscle actin in odontogenic cysts and tumors. | Annegowda, VM., et al. 2018. J Oral Maxillofac Pathol. 22: 188-192. PMID: 30158770
- Distinction between smooth muscle, fibroblasts and endothelial cells in culture by the use of fluoresceinated antibodies against smooth muscle actin. | Chamley, JH., et al. 1977. Cell Tissue Res. 177: 445-57. PMID: 319908
- Alpha-Smooth Muscle Actin Expression and Parafoveal Blood Flow Pathways Are Altered in Preclinical Diabetic Retinopathy. | An, D., et al. 2022. Invest Ophthalmol Vis Sci. 63: 8. PMID: 35522303
- A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA. | Minty, AJ., et al. 1982. Cell. 30: 185-92. PMID: 6897014
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Muscle Actin Antibody (4i346) | sc-71625 | 200 µg/ml | $316.00 |