Date published: 2026-4-27

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Muscimol hydrobromide (CAS 18174-72-6)

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Alternate Names:
5-(aminomethyl)-1,2-oxazol-3-one hydrobromide
Application:
Muscimol hydrobromide is a potent but toxic structural analog of g-aminobutyric acid (GABA)
CAS Number:
18174-72-6
Molecular Weight:
195.01
Molecular Formula:
C4H6N2O2•HBr
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Muscimol Hydrobromide is a compound widely used in neuroscientific research for its agonist activity at certain receptor sites. It is instrumental in the study of the receptors′ function in regulating neuronal excitability and synaptic transmission. Researchers use Muscimol Hydrobromide to modulate the activity of these receptors in experimental models, allowing for the analysis of their role in neural circuits and behavior. The compound is also used in electrophysiological experiments to help determine the ionic mechanisms underlying the receptors′ effects on neurons. In addition, the use of Muscimol Hydrobromide in brain slice preparations provides insights into the regional and cellular distribution of these receptors within the central nervous system.


Muscimol hydrobromide (CAS 18174-72-6) References

  1. Sleep is differently modulated by basal forebrain GABA(A) and GABA(B) receptors.  |  Manfridi, A., et al. 2001. Am J Physiol Regul Integr Comp Physiol. 281: R170-5. PMID: 11404291
  2. GABAA-5-HT1A receptor interaction in the mediobasal hypothalamus.  |  Guptarak, J., et al. 2004. Brain Res. 1027: 144-50. PMID: 15494165
  3. [Effects of intra-amygdala injection of GABA(A)-receptor agonist and antagonist on behavior of active and passive rabbits in negative emotional situations].  |  Rysakova, MP. and Pavlova, IV. 2012. Zh Vyssh Nerv Deiat Im I P Pavlova. 62: 332-45. PMID: 22891579
  4. [Behavior of high- and low-anxiety rats after modulation of GABAergic transmission in basolateral amygdala].  |  Rysakova, MP. and Pavlova, IV. 2014. Ross Fiziol Zh Im I M Sechenova. 100: 736-49. PMID: 25665398
  5. Effects of Injection of Gamma-Aminobutyric Acid Agonists into the Nucleus Accumbens on Naloxone-Induced Morphine Withdrawal.  |  Topkara, B., et al. 2017. Pharmacology. 100: 131-138. PMID: 28637045
  6. Effects of sodium n-dipropylacetate, muscimol hydrobromide and (R,S) nipecotic acid amide on isolation-induced aggressive behavior in mice.  |  Puglisi-Allegra, S. and Mandel, P. 1980. Psychopharmacology (Berl). 70: 287-90. PMID: 6777802
  7. Involvement of the GABAergic system on shock-induced aggressive behavior in two strains of mice.  |  Puglisi-Allegra, S., et al. 1981. Pharmacol Biochem Behav. 14 Suppl 1: 13-8. PMID: 6787619
  8. Injections of muscimol into the median raphe nucleus produce hippocampal theta rhythm in the urethane anesthetized rat.  |  Kinney, GG., et al. 1995. Psychopharmacology (Berl). 120: 244-8. PMID: 8524970

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Muscimol hydrobromide, 10 mg

sc-218894
10 mg
$423.00