Molecular structure of Muristerone A, CAS Number: 38778-30-2
Muristerone A (CAS 38778-30-2)
Alternate Names:
2β,3β,5β,11α,14α,20R,22R-Heptahydroxycholest-7-en-6-one
Application:
Muristerone A is a potent inducer of ecdysone-inducible genes
CAS Number:
38778-30-2
Purity:
≥95%
Molecular Weight:
496.63
Molecular Formula:
C27H44O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Muristerone A is a phytoecdysteroid analog of ecdysone which induces genes in mammalian cells and causes apoptosis in cells transfected with wild-type Bax. Studies indicate that Muristerone A regulates the metamorphosis of Drosophila melanogaster, while causing a response to G2 cell cycle arrest. Ecdysone is a major molting hormone in some insects and has protective effects in plants. Muristerone A is a useful compound in regulating the effects of ecdysone in these various phyla.
Muristerone A (CAS 38778-30-2) References
- Impairment of the proapoptotic activity of Bax by missense mutations found in gastrointestinal cancers. | Gil, J., et al. 1999. Cancer Res. 59: 2034-7. PMID: 10232581
- Reporter-linked monitoring of transgene expression in living cells using the ecdysone-inducible promoter system. | Lüers, GH., et al. 2000. Eur J Cell Biol. 79: 653-7. PMID: 11043406
- Identification of ligands and coligands for the ecdysone-regulated gene switch. | Saez, E., et al. 2000. Proc Natl Acad Sci U S A. 97: 14512-7. PMID: 11114195
- Suppression of the tumorigenicity of mutant p53-transformed rat embryo fibroblasts through expression of a newly cloned rat nonmuscle myosin heavy chain-B. | Yam, JW., et al. 2001. Oncogene. 20: 58-68. PMID: 11244504
- The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells. | Constantino, S., et al. 2001. Eur Cytokine Netw. 12: 365-7. PMID: 11399528
- Muristerone A-induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering. | Patrick, CW., et al. 2001. Tissue Eng. 7: 303-11. PMID: 11429150
- Transfection of an inducible trout anion exchanger (AE1) into HEK-EcR cells. | Davis, EM., et al. 2002. J Exp Zool. 293: 46-57. PMID: 12115918
- Juvenile hormone potentiates ecdysone receptor-dependent transcription in a mammalian cell culture system. | Henrich, VC., et al. 2003. Insect Biochem Mol Biol. 33: 1239-47. PMID: 14599496
- Influence of hormone on intracellular localization of the Drosophila melanogaster ecdysteroid receptor (EcR). | Nieva, C., et al. 2007. Cell Signal. 19: 2582-7. PMID: 17884338
- A comparative study examining the cytotoxicity of inducible gene expression system ligands in different cell types. | Xie, J., et al. 2008. Toxicol In Vitro. 22: 261-6. PMID: 17928190
- Identification of Ecdysone Hormone Receptor Agonists as a Therapeutic Approach for Treating Filarial Infections. | Mhashilkar, AS., et al. 2016. PLoS Negl Trop Dis. 10: e0004772. PMID: 27300294
- Cytostatic and Cytotoxic Natural Products against Cancer Cell Models. | Ling, T., et al. 2019. Molecules. 24: PMID: 31130671
- Characterization and partial purification of the Drosophila Kc cell ecdysteroid receptor. | Landon, TM., et al. 1988. J Biol Chem. 263: 4693-7. PMID: 3127389
- Ecdysone-inducible gene expression in mammalian cells and transgenic mice. | No, D., et al. 1996. Proc Natl Acad Sci U S A. 93: 3346-51. PMID: 8622939
- Inducible expression of erythrocyte band 3 protein. | Timmer, RT. and Gunn, RB. 1999. Am J Physiol. 276: C66-75. PMID: 9886921
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Muristerone A, 1 mg | sc-301176 | 1 mg | $150.00 |