MuRF1 Antibody (SW-53): sc-134397

MuRF1 Antibody (SW-53) is a mouse monoclonal IgG1 antibody that detects MuRF1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). MuRF1, or muscle-specific RING finger protein 1, plays a crucial role in muscle atrophy, particularly in conditions that provoke muscle wasting, such as cancer and sepsis. MuRF1 is primarily located in the sarcomere, the fundamental unit of muscle contraction, where MuRF1 is involved in the regulation of protein degradation pathways. The localization of MuRF1 in the sarcomere is significant because MuRF1 allows for the targeted degradation of contractile proteins during muscle atrophy, thereby facilitating the remodeling of muscle tissue in response to stressors. Furthermore, MuRF1′s interaction with key signaling molecules, such as Titin kinase, underscores MuRF1′s importance in maintaining muscle integrity and function. Elevated levels of MuRF1 are indicative of pathological conditions characterized by increased reactive oxygen species, highlighting MuRF1′s potential as a biomarker for muscle-related diseases. Anti-MuRF1 antibody (SW-53) is an essential tool for researchers investigating the mechanisms of muscle atrophy and the therapeutic potential of targeting the IKKbeta/NF-kappaB/MuRF1 pathway.

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MuRF1 Antibody (SW-53) References:

1. The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy.  |  Foletta, VC., et al. 2011. Pflugers Arch. 461: 325-35. PMID: 21221630
2. Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1.  |  Bodine, SC. and Baehr, LM. 2014. Am J Physiol Endocrinol Metab. 307: E469-84. PMID: 25096180
3. A muscle-specific MuRF1-E2 network requires stabilization of MuRF1-E2 complexes by telethonin, a newly identified substrate.  |  Polge, C., et al. 2018. J Cachexia Sarcopenia Muscle. 9: 129-145. PMID: 29271608
4. Muscle RING-finger protein-1 (MuRF1) functions and cellular localization are regulated by SUMO1 post-translational modification.  |  Heras, G., et al. 2019. J Mol Cell Biol. 11: 356-370. PMID: 29868881
5. MuRF1/TRIM63, Master Regulator of Muscle Mass.  |  Peris-Moreno, D., et al. 2020. Int J Mol Sci. 21: PMID: 32933049
6. Identification of the MuRF1 Skeletal Muscle Ubiquitylome Through Quantitative Proteomics.  |  Baehr, LM., et al. 2021. Function (Oxf). 2: zqab029. PMID: 34179788
7. MuRF1 deficiency prevents age-related fat weight gain, possibly through accumulation of PDK4 in skeletal muscle mitochondria in older mice.  |  Sugiura, K., et al. 2022. J Orthop Res. 40: 1026-1038. PMID: 34185335
8. Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility.  |  Adams, V., et al. 2022. J Cachexia Sarcopenia Muscle. 13: 1565-1581. PMID: 35301823
9. Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth.  |  Neyroud, D., et al. 2023. Commun Biol. 6: 519. PMID: 37179425
10. Targeting MuRF1 to Combat Skeletal Muscle Wasting in Cardiac Cachexia: Mechanisms and Therapeutic Prospects.  |  Liu, X., et al. 2024. Med Sci Monit. 30: e945211. PMID: 39434377

The preferred MuRF1 antibody is MuRF1 Antibody (C-11): sc-398608.