Mucin 7/MUC7 Antibody (1C10): sc-517138
- Mucin 7/MUC7 Antibody (1C10) is a mouse monoclonal IgG2a κ Mucin 7/MUC7 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against amino acids 36-135 representing partial length Mucin 7 of human origin
- recommended for detection of Mucin 7 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mucin 7/MUC7 Antibody (1C10). This work is in progress.
Mucin 7 Antibody (1C10) is a mouse monoclonal IgG2a kappa light chain antibody that detects Mucin 7 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Mucin 7 antibody (1C10) is available as a non-conjugated format. Mucin 7, also known as MG2 or mucin glycoprotein 2, plays a crucial role in forming protective mucosal barriers, essential for maintaining epithelial surface integrity and preventing pathogen invasion. This low-molecular-mass salivary mucin is secreted as a soluble monomer and primarily expressed in human submandibular and sublingual secretions, as well as in mucous acinar cells. Mucin 7′s ability to bind various microbes is vital for immune defense, and this interaction is facilitated by a cysteine-containing domain located in the N-terminal region of MUC7. MUC7 expression is selectively observed in bladder cancer cell lines and samples of invasive transitional cell carcinomas, indicating potential use as a biomarker for malignant transformation in bladder urothelium. MUC7 expression is regulated by retinoic acid and thyroid hormones, highlighting hormonal control over mucin gene expression and implications in various epithelial cancers.
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Mucin 7/MUC7 Antibody (1C10) References:
- In-situ hybridization localized MUC7 mucin gene expression to the mucous acinar cells of human and MUC7-transgenic mouse salivary glands. | Khan, SH., et al. 1998. Glycoconj J. 15: 1125-32. PMID: 10372967
- Tissue-specific expression of human salivary mucin gene, MUC7, in transgenic mice. | Bobek, LA., et al. 1998. Transgenic Res. 7: 195-204. PMID: 10461391
- Mammalian reproductive tract mucins. | Lagow, E., et al. 1999. Hum Reprod Update. 5: 280-92. PMID: 10465520
- The recombinant N-terminal region of human salivary mucin MG2 (MUC7) contains a binding domain for oral Streptococci and exhibits candidacidal activity. | Liu, B., et al. 2000. Biochem J. 345 Pt 3: 557-64. PMID: 10642514
- Regulation of mucous differentiation and mucin gene expression in the tracheobronchial epithelium. | Gray, T., et al. 2001. Toxicology. 160: 35-46. PMID: 11246122
- Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7). | Bobek, LA., et al. 1993. J Biol Chem. 268: 20563-9. PMID: 7690757
- Selection of tumor antigens as targets for immune attack using immunohistochemistry: protein antigens. | Zhang, S., et al. 1998. Clin Cancer Res. 4: 2669-76. PMID: 9829729
- Differential mucin MUC7 gene expression in invasive bladder carcinoma in contrast to uniform MUC1 and MUC2 gene expression in both normal urothelium and bladder carcinoma. | Retz, M., et al. 1998. Cancer Res. 58: 5662-6. PMID: 9865718
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mucin 7/MUC7 Antibody (1C10) | sc-517138 | 100 µg/ml | $316.00 |