Mucin 6/MUC6 Antibody (0.N.459): sc-71623

Mucin 6 Antibody (0.N.459) is a mouse monoclonal IgG1 antibody that detects Mucin 6 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Mucin 6 is a large glycoprotein that plays a crucial role in protecting the gastrointestinal tract by forming a protective mucous barrier. Anti-Mucin 6 antibody (0.N.459) specifically targets proteins primarily located in the stomach and gall bladder, where Mucin 6 is secreted into the deeper mucosal folds, providing a vital defense against pathogens and mechanical damage. Notably, Mucin 6 carries specific glycan structures, such as GlcNAcα1-->4Galβ-->R, which are essential for function and stability in the mucosal environment. Alterations in Mucin 6 expression have been observed in gastric cancer, highlighting potential roles as a biomarker for disease progression. Additionally, Mucin 6 is transiently expressed in the nephrogenic zone of the kidney during early development, indicating involvement in renal morphogenesis. Mucin 6 monoclonal antibody (0.N.459) serves as an invaluable tool for researchers studying gastrointestinal health, cancer biology, and developmental processes.

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Mucin 6/MUC6 Antibody (0.N.459) References:

1. Immunohistochemical detection of gastric mucin in normal and disease states.  |  Taylor, KL., et al. 1998. Oncol Res. 10: 465-73. PMID: 10223622
2. Expression of the MUC 6 mucin gene in development of the human kidney and male genital ducts.  |  Reid, CJ. and Harris, A. 1999. J Histochem Cytochem. 47: 817-22. PMID: 10330458
3. Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: gastric foveolar type is associated with aggressive tumour behaviour.  |  Aishima, S., et al. 2006. Histopathology. 49: 35-44. PMID: 16842244
4. Higher gastric mucin secretion and lower gastric acid output in first-degree relatives of gastric cancer patients.  |  Vilkin, A., et al. 2008. J Clin Gastroenterol. 42: 36-41. PMID: 18097287
5. Roles of gastric mucin-type O-glycans in the pathogenesis of Helicobacter pylori infection.  |  Kobayashi, M., et al. 2009. Glycobiology. 19: 453-61. PMID: 19150806
6. Immunohistochemical analysis of pyloric gland adenomas using a series of Mucin 2, Mucin 5AC, Mucin 6, CD10, Ki67 and p53.  |  Vieth, M., et al. 2010. Virchows Arch. 457: 529-36. PMID: 20827489
7. Decreased expression of gastric gland mucin-specific glycan α1,4-linked N-acetylglucosamine on its scaffold mucin 6 is associated with malignant potential of pyloric gland adenoma of the stomach.  |  Yamanoi, K., et al. 2015. Histopathology. 67: 898-904. PMID: 25929994
8. Structural Diversity of Human Gastric Mucin Glycans.  |  Jin, C., et al. 2017. Mol Cell Proteomics. 16: 743-758. PMID: 28461410
9. Kinesin Family Member B18 Is Related to Gastric Mucin Phenotype and Contributes to Gastric Cancer Progression by Regulating Epithelial-Mesenchymal Transition.  |  Ishikawa, A., et al. 2024. Oncology. 102: 354-365. PMID: 37812924
10. Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression.  |  Ho, SB., et al. 1995. Gastroenterology. 109: 735-47. PMID: 7657101

The preferred Mucin 6/MUC6 antibody is Mucin 6/MUC6 Antibody (CLH5): sc-33668.