Mucin 3/MUC3 Antibody (M3.1): sc-7315

Mucin 3 Antibody (M3.1) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Mucin 3 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Mucin 3 antibody (M3.1) is available as a non-conjugated format. Mucin 3, also known as mucin 3A, plays a crucial role in forming protective mucus layers in various tissues, particularly in the gastrointestinal tract, where Mucin 3 contributes to the maintenance of epithelial integrity and barrier function. Mucin 3 is essential for trapping pathogens and particulates, thereby preventing infections and inflammation. Mucin 3 expression is not only vital for normal physiological processes but also has implications in disease states, as aberrant Mucin 3 expression has been linked to various cancers, including colorectal cancer. The structure of Mucin 3, characterized by its highly glycosylated nature and the presence of variable number tandem repeats (VNTRs), allows Mucin 3 to interact with other proteins and cells, enhancing its protective functions. Mucin 3 monoclonal antibody (M3.1) is an invaluable tool for researchers studying the role of mucins in health and disease, providing insights into their function and potential as therapeutic targets.

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Mucin 3/MUC3 Antibody (M3.1) References:

1. The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region.  |  Gum, JR., et al. 1992. J Biol Chem. 267: 21375-83. PMID: 1400449
2. Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response.  |  Geng, H., et al. 2006. J Immunol. 176: 1411-20. PMID: 16424168
3. Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity.  |  Frisancho-Kiss, S., et al. 2006. J Immunol. 176: 6411-5. PMID: 16709797
4. Selective induction of mucin-3 by hypoxia in intestinal epithelia.  |  Louis, NA., et al. 2006. J Cell Biochem. 99: 1616-27. PMID: 16823775
5. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface.  |  Cao, E., et al. 2007. Immunity. 26: 311-21. PMID: 17363302
6. Molecular cloning of cDNAs derived from a novel human intestinal mucin gene.  |  Gum, JR., et al. 1990. Biochem Biophys Res Commun. 171: 407-15. PMID: 2393399
7. Cloning and sequencing of a human pancreatic tumor mucin cDNA.  |  Lan, MS., et al. 1990. J Biol Chem. 265: 15294-9. PMID: 2394722
8. Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen.  |  Siddiqui, J., et al. 1988. Proc Natl Acad Sci U S A. 85: 2320-3. PMID: 2895474
9. Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.  |  Pandey, P., et al. 1995. Cancer Res. 55: 4000-3. PMID: 7664271

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mucin 3/MUC3 Antibody (M3.1) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-Mucin 3/MUC3 Antibody (M3.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mucin 3/MUC3 Antibody (M3.1) Specifications

Alternate Product Name: MUC3A

Product Clone Name: M3.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Mucin 3

Epitope Species: human

Product Reactivity/Detection: Mucin 3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for Mucin 3/MUC3 Antibody (M3.1): N/A