Mucin 16/MUC16 Antibody (X325): sc-52096
- Mucin 16/MUC16 Antibody (X325) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against Mucin 16 purified from human ovarian carcinoma
- recommended for detection of epitope specificity group B of Mucin 16 of human origin by WB, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mucin 16/MUC16 Antibody (X325). This work is in progress.
Mucin 16 Antibody (X325) is a mouse monoclonal IgG1 antibody that detects Mucin 16 in human samples through applications such as western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Mucin 16, also known as CA125, is a high molecular weight glycoprotein encoded by the MUC16 gene, which plays a critical role in protecting and maintaining the epithelial lining, particularly in ovarian cancer. Mucin 16 consists of three distinct domains: a carboxy terminal domain, an extracellular domain, and an amino terminal domain, which contribute to function as a tumor-associated antigen. The extracellular domain facilitates interactions with other cells and the extracellular matrix, influencing cell signaling and adhesion processes. Mucin 16 is predominantly expressed on epithelial cell surfaces and secreted into bodily fluids, serving as a biomarker for monitoring epithelial ovarian cancer progression. The hydrophilic nature and membrane association of Mucin 16 suggest involvement in various physiological processes, including immune response modulation and cellular communication, making Mucin 16 a significant target for both diagnostic and therapeutic applications in oncology.
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Mucin 16/MUC16 Antibody (X325) References:
- CA-125 monitoring in ovarian cancer: patient survey responses to the results of the MRC/EORTC CA-125 Surveillance Trial. | Markman, M., et al. 2010. Oncology. 78: 1-2. PMID: 20215782
- Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. | Koyama, Y., et al. 2017. J Clin Invest. 127: 1254-1270. PMID: 28287406
- CA125 effects on humoral immunosuppression. | Kline, JB. and Nicolaides, NC. 2017. Aging (Albany NY). 9: 2010-2011. PMID: 29016358
- Combined Preoperative LMR and CA125 for Prognostic Assessment of Ovarian Cancer. | Tang, Y., et al. 2020. J Cancer. 11: 3165-3171. PMID: 32231720
- Mucin 16 Promotes Colorectal Cancer Development and Progression Through Activation of Janus Kinase 2. | Liu, Z., et al. 2022. Dig Dis Sci. 67: 2195-2208. PMID: 33982216
- HE4 and CA125 serum biomarker monitoring in women with epithelial ovarian cancer. | Samborski, A., et al. 2022. Tumour Biol. 44: 205-213. PMID: 36189508
- Individual recombinant repeats of MUC16 display variable binding to CA125 antibodies. | Wang, CW., et al. 2023. Cancer Biomark. 37: 85-94. PMID: 37248884
- Production of CA125 with Tn antigens using a glycosylphosphatidylinositol anchoring system. | Tang, YH., et al. 2024. J Biochem. 176: 23-34. PMID: 38382634
- Correlating the KELIM (CA125 elimination rate constant K) score and the chemo-response score as predictors of chemosensitivity in patients with advanced ovarian carcinoma. | Piedimonte, S., et al. 2024. Gynecol Oncol. 187: 92-97. PMID: 38735145
- Theranostic Capacity of a Mucin 16-targeted Antibody for Ovarian Cancer. | Tan, KV. 2024. Radiol Imaging Cancer. 6: e249013. PMID: 38819265
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mucin 16/MUC16 Antibody (X325) | sc-52096 | 100 µg/ml | $316.00 |