Mucin 1/MUC1 Antibody (M8C9): sc-52092
- Mucin 1/MUC1 Antibody (M8C9) is a mouse monoclonal IgG provided at 100 µg/ml
- raised against high moleular weight glycoprotein from human milk-fat globule molecule
- recommended for detection of VNTR5 and VNTR20 recombinant unglycosylated fragments of Mucin 1 protein and underglycosylated Mucin 1 of human origin by WBIPIF
- See Mucin 1/MUC1 (VU4H5): sc-7313 for Mucin 1/MUC1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mucin 1/MUC1 Antibody (M8C9). This work is in progress.
Mucin 1 Antibody (M8C9) is a mouse monoclonal IgG antibody that detects Mucin 1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Mucin 1 plays a crucial role in cell signaling and adhesion, acting as a protective barrier on epithelial surfaces and contributing to the maintenance of tissue integrity. Mucin 1 (M8C9) antibody enables research into aberrant expression patterns, particularly significant in cancer where Mucin 1 is often overexpressed in various epithelial tumors, including breast carcinomas, which can lead to enhanced tumor progression and metastasis. Understanding the function of Mucin 1 is vital for developing targeted therapies and diagnostic tools in oncology, as Mucin 1 may serve as a potential biomarker for tumor aggressiveness and patient prognosis. Anti-Mucin 1 antibody (M8C9) is an essential tool for researchers investigating this protein′s role in cancer biology and other related fields.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Mucin 1/MUC1 Antibody (M8C9) References:
- Mucin 1 downregulation associates with corticosteroid resistance in chronic rhinosinusitis with nasal polyps. | Milara, J., et al. 2015. J Allergy Clin Immunol. 135: 470-6. PMID: 25159466
- Presentation of underglycosylated mucin 1 in pancreatic adenocarcinoma (PDAC) at early stages. | Lo, ST., et al. 2016. Am J Cancer Res. 6: 1986-1995. PMID: 27725904
- Mucin 1 (Muc1) Deficiency in Female Mice Leads to Temporal Skeletal Changes During Aging. | Brum, AM., et al. 2018. JBMR Plus. 2: 341-350. PMID: 30460337
- Targeted delivery of doxorubicin by magnetic mesoporous silica nanoparticles armed with mucin-1 aptamer. | Siminzar, P., et al. 2020. J Drug Target. 28: 92-101. PMID: 31062625
- Downregulated Mucin 1 alleviates paclitaxel resistance in non‑small cell lung cancer cells. | Xu, H., et al. 2020. Mol Med Rep. 22: 2966-2972. PMID: 32945387
- Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor. | Zhao, Y., et al. 2020. Animals (Basel). 11: PMID: 33375426
- Mucin 1 as a Molecular Target of a Novel Diisoquinoline Derivative Combined with Anti-MUC1 Antibody in AGS Gastric Cancer Cells. | Gornowicz, A., et al. 2021. Molecules. 26: PMID: 34770912
- MUC1 expressing tumor growth was retarded after human mucin 1 (MUC1) plasmid DNA immunization. | Son, HY., et al. 2022. Int J Immunopathol Pharmacol. 36: 3946320221112358. PMID: 35839304
- α1,4-Linked N-acetylglucosamine suppresses gastric cancer development by inhibiting Mucin-1-mediated signaling. | Fujii, C., et al. 2022. Cancer Sci. 113: 3852-3863. PMID: 35959971
- Baseline Blood Levels of Mucin-1 Are Associated with Crucial On-Treatment Adverse Outcomes in Patients with Idiopathic Pulmonary Fibrosis Receiving Antifibrotic Pirfenidone. | Huang, TH., et al. 2024. Biomedicines. 12: PMID: 38398004
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mucin 1/MUC1 Antibody (M8C9) | sc-52092 | 100 µg/ml | $322.00 |