Molecular structure of MTSL, CAS Number: 81213-52-7
MTSL (CAS 81213-52-7)
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Alternate Names:
MTSL also known as (1-Oxyl-2,2,5,5-tetramethylpyrroline-3- methyl)methanethiosulfonate; MTS; MTSSL; Otmpmms; Otpm-mts; 2,5-Dihydro-2,2,5,5-tetramethyl-3-[[(methylsulfonyl)thio]methyl]-1H-pyrrol-1-yloxy; (1-Oxyl-2,2,5,5-tetramethyl-delta(3)-pyrroline-3-methyl)methanethiosulfonate; (2,2,5,5-tetramethyl-3-{[(methylsulfonyl)sulfanyl]methyl}-2,5-dihydro-1H-pyrrol-1-yl)oxidanyl
Application:
MTSL is a highly reactive, thiol-specific spin-label which is a specific conformational probe of the thiol site structure
CAS Number:
81213-52-7
Purity:
≥98%
Molecular Weight:
264.38
Molecular Formula:
C10H18NO3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MTSL is a highly reactive, thiol-specific spin-label. MTSL is a specific conformational probe of thiol site structure by its minimal rotational freedom and distance from the covalent disulfide linkage to the macromolecule under study. MTSL can be used to label cysteine residues in proteins, site-directed labeling and SDS labeling. MTSL allows protein structure and protein dynamics determination and the study of protein-protein and protein-oligonucleotide interactions.
MTSL (CAS 81213-52-7) References
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- Conformation of the closed channel state of colicin A in proteoliposomes: an umbrella model. | Padmavathi, PV. and Steinhoff, HJ. 2008. J Mol Biol. 378: 204-14. PMID: 18353363
- Conformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling. | Huang, H. and Cafiso, DS. 2008. Biochemistry. 47: 12380-8. PMID: 18956883
- New insights into the role of the disordered WIP N-terminal domain revealed by NMR structural characterization. | Elazari-Shalom, H., et al. 2015. FEBS J. 282: 700-14. PMID: 25495558
- A combined NMR and computational approach to investigate peptide binding to a designed Armadillo repeat protein. | Ewald, C., et al. 2015. J Mol Biol. 427: 1916-33. PMID: 25816772
- Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. | Papaioannou, D., et al. 2016. Protein Sci. 25: 627-37. PMID: 26645482
- Distance measurements in peridinin-chlorophyll a-protein by light-induced PELDOR spectroscopy. Analysis of triplet state localization. | Di Valentin, M., et al. 2016. Biochim Biophys Acta. 1857: 1909-1916. PMID: 27659505
- Optimal Tikhonov regularization for DEER spectroscopy. | Edwards, TH. and Stoll, S. 2018. J Magn Reson. 288: 58-68. PMID: 29414064
- Nucleotide Spin Labeling for ESR Spectroscopy of ATP-Binding Proteins. | Muok, AR., et al. 2018. Appl Magn Reson. 49: 1385-1395. PMID: 30686862
- A molecular switch regulating transcriptional repression and activation of PPARγ. | Shang, J., et al. 2020. Nat Commun. 11: 956. PMID: 32075969
- Long-range structural preformation in yes-associated protein precedes encounter complex formation with TEAD. | Feichtinger, M., et al. 2022. iScience. 25: 104099. PMID: 35378854
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTSL, 10 mg | sc-208677 | 10 mg | $170.00 | |||
MTSL, 50 mg | sc-208677A | 50 mg | $400.00 |