Molecular structure of MTS-TPAE
MTS-TPAE
Alternate Names:
2-(Tripentylammonium)ethyl Methanethiosulfonate Bromide
Molecular Weight:
446.55
Molecular Formula:
C18H40NO2S2•Br
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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MTS-TPAE is a water soluble, bulkier analogue of the charged MTS reagent MTSET. Charged MTS reagents have been used successfully with SCAM (substituted cysteine accessibility method) to probe the topology and function of a number of ligand-gated ion channels and transporter proteins. MTS-TPAE is used in the study to investigate ion access pathways and structural changes in P2X receptor channels. By covalently binding to specific cysteine residues introduced into the P2X7 receptor, MTS-TPAE can inhibit conformational changes necessary for channel opening, providing insights into the receptor′s structure-function relationship and the mechanisms by which P2X7-specific antagonists inhibit receptor activation.
MTS-TPAE References
- Pore-opening mechanism in trimeric P2X receptor channels. | Li, M., et al. 2010. Nat Commun. 1: 44. PMID: 20975702
- Ion access pathway to the transmembrane pore in P2X receptor channels. | Kawate, T., et al. 2011. J Gen Physiol. 137: 579-90. PMID: 21624948
- The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways. | John, SA., et al. 2013. Proc Natl Acad Sci U S A. 110: 7500-5. PMID: 23589872
- Principles and properties of ion flow in P2X receptors. | Samways, DS., et al. 2014. Front Cell Neurosci. 8: 6. PMID: 24550775
- Structural basis for subtype-specific inhibition of the P2X7 receptor. | Karasawa, A. and Kawate, T. 2016. Elife. 5: PMID: 27935479
- An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels. | Ase, AR., et al. 2019. Front Cell Neurosci. 13: 121. PMID: 31024257
- Hearing loss mutations alter the functional properties of human P2X2 receptor channels through distinct mechanisms. | George, B., et al. 2019. Proc Natl Acad Sci U S A. 116: 22862-22871. PMID: 31636190
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTS-TPAE, 10 mg | sc-215397 | 10 mg | $375.00 |