Molecular structure of MTPG, CAS Number: 169209-66-9
MTPG (CAS 169209-66-9)
Alternate Names:
(RS)-α-Methyl-4-tetrazolylphenylglycine
Application:
MTPG is a group II/group III mGluR antagonist
CAS Number:
169209-66-9
Molecular Weight:
233.23
Molecular Formula:
C10H11N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MTPG is a group II/group III mGlu antagonist, showing selectivity for group II in electrophysiological studies. MTPG is a potent antagonist for (1S,3S)-ACPD-sensitive receptors; preference for group II mGluR.
MTPG (CAS 169209-66-9) References
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- Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists. | Folbergrová, J., et al. 2001. Brain Res. 908: 120-9. PMID: 11454322
- Group II metabotropic glutamate receptor-mediated regulation of dopamine release from slices of rat nucleus accumbens. | Chaki, S., et al. 2006. Neurosci Lett. 404: 182-6. PMID: 16781059
- Blockade of α2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity. | Hayashida, KI., et al. 2018. Neurosci Lett. 676: 41-45. PMID: 29627342
- New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. | Jane, DE., et al. 1995. Neuropharmacology. 34: 851-6. PMID: 8532166
- Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices. | Bushell, TJ., et al. 1996. Br J Pharmacol. 117: 1457-62. PMID: 8730739
- Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors. | Bedingfield, JS., et al. 1996. Eur J Pharmacol. 309: 71-8. PMID: 8864696
- Activation of group-II metabotropic glutamate receptors blocks induction of long-term potentiation and depotentiation in area CA1 of the rat in vivo. | Hölscher, C., et al. 1997. Eur J Pharmacol. 322: 155-63. PMID: 9098682
- Pharmacological characterization of metabotropic glutamate receptors linked to the inhibition of adenylate cyclase activity in rat striatal slices. | Schaffhauser, H., et al. 1997. Neuropharmacology. 36: 933-40. PMID: 9257937
- PCCG-IV inhibits the induction of long-term potentiation in the dentate gyrus in vitro. | Huang, L., et al. 1997. Eur J Pharmacol. 332: 161-5. PMID: 9286617
Inhibitor of:
mGluR-2, mGluR-3, mGluR-4, mGluR-6, mGluR-7, and mGLuR-8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTPG, 5 mg | sc-204106 | 5 mg | $119.00 | |||
MTPG, 50 mg | sc-204106A | 50 mg | $709.00 |