MTMR2 Antibody (F-1): sc-365184
- MTMR2 Antibody (F-1) is a mouse monoclonal IgG1 κ MTMR2 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 47-77 near the N-terminus of MTMR2 of human origin
- MTMR2 Antibody (F-1) is recommended for detection of MTMR2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- Anti-MTMR2 Antibody (F-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for MTMR2 Antibody (F-1) for WB applications. This reagent is now offered in a bundle with MTMR2 Antibody (F-1) (see ordering information below).
MTMR2 Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects MTMR2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MTMR2 (F-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MTMR2 protein is a member of the myotubularin family, which consists of eukaryotic phosphatases that play a crucial role in lipid metabolism by hydrolyzing phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bisphosphate, thereby regulating cellular signaling pathways. MTMR2′s importance lies in its involvement in the regulation of membrane trafficking and autophagy, processes that are vital for maintaining cellular homeostasis and function. MTMR2 interacts with MTMR5, which enhances enzymatic activity and influences localization within the cell. Mutations in MTMR2 gene are linked to autosomal recessive Charcot-Marie-Tooth type 4B1, a hereditary neuropathy characterized by demyelination and reduced nerve conduction velocities, highlighting MTMR2′s significance in neurological health. MTMR2′s interactions with other family members, such as MTMR3 and MTMR4, suggest a complex network of regulatory mechanisms that are essential for proper cellular function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MTMR2 Antibody (F-1) References:
- Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway. | Blondeau, F., et al. 2000. Hum Mol Genet. 9: 2223-9. PMID: 11001925
- Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. | Kim, SA., et al. 2003. Proc Natl Acad Sci U S A. 100: 4492-7. PMID: 12668758
- Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. | Mochizuki, Y. and Majerus, PW. 2003. Proc Natl Acad Sci U S A. 100: 9768-73. PMID: 12890864
- Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1. | Srivastava, S., et al. 2006. Mol Biol Cell. 17: 146-54. PMID: 16251351
- Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2. | Berger, P., et al. 2006. Hum Mol Genet. 15: 569-79. PMID: 16399794
- Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. | Lorenzo, O., et al. 2006. J Cell Sci. 119: 2953-9. PMID: 16787938
- Mutations in the MTM1 gene implicated in X-linked myotubular myopathy. ENMC International Consortium on Myotubular Myopathy. European Neuro-Muscular Center. | Laporte, J., et al. 1997. Hum Mol Genet. 6: 1505-11. PMID: 9305655
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTMR2 Antibody (F-1) | sc-365184 | 200 µg/ml | $316.00 | |||
MTMR2 Antibody (F-1): m-IgG Fc BP-HRP Bundle | sc-552006 | 200 µg Ab; 10 µg BP | $354.00 | |||
MTMR2 Antibody (F-1) AC | sc-365184 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MTMR2 Antibody (F-1) HRP | sc-365184 HRP | 200 µg/ml | $316.00 | |||
MTMR2 Antibody (F-1) FITC | sc-365184 FITC | 200 µg/ml | $330.00 | |||
MTMR2 Antibody (F-1) PE | sc-365184 PE | 200 µg/ml | $343.00 | |||
MTMR2 Antibody (F-1) Alexa Fluor® 488 | sc-365184 AF488 | 200 µg/ml | $357.00 | |||
MTMR2 Antibody (F-1) Alexa Fluor® 546 | sc-365184 AF546 | 200 µg/ml | $357.00 | |||
MTMR2 Antibody (F-1) Alexa Fluor® 594 | sc-365184 AF594 | 200 µg/ml | $357.00 | |||
MTMR2 Antibody (F-1) Alexa Fluor® 647 | sc-365184 AF647 | 200 µg/ml | $357.00 | |||
MTMR2 Antibody (F-1) Alexa Fluor® 680 | sc-365184 AF680 | 200 µg/ml | $357.00 | |||
MTMR2 Antibody (F-1) Alexa Fluor® 790 | sc-365184 AF790 | 200 µg/ml | $357.00 | |||
MTMR2 (F-1) Neutralizing Peptide | sc-365184 P | 100 µg/0.5 ml | $68.00 |