MsrA Antibody (1C8): sc-59619

MsrA Antibody (1C8) is a mouse monoclonal IgG1 antibody that detects MsrA protein of mouse, rat, and human origin by immunoprecipitation (IP) and enzyme-linked immunosorbent assay (ELISA). Anti-MsrA antibody (1C8) is available as a non-conjugated format. MsrA, or methionine sulfoxide reductase A, plays a crucial role in cellular defense against oxidative stress by catalyzing the reduction of oxidized methionine residues, which are particularly vulnerable to damage from reactive oxygen species (ROS) such as hydrogen peroxide and superoxide ions. This enzymatic activity is vital for maintaining protein function and cellular integrity, especially in tissues highly susceptible to oxidative damage, such as brain and liver. MsrA is widely expressed across various species, including humans, and is found in high concentrations in liver, kidney, and immune cells, highlighting MsrA importance in both metabolic and immune responses. MsrA activity has been shown to decrease in brains of individuals with Alzheimer′s disease, suggesting a protective role against neurodegeneration. MsrA ability to restore oxidized methionine residues not only aids in protein repair but also enhances cellular resilience to oxidative stress, making MsrA a significant target for research into age-related diseases and potential therapeutic interventions.

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MsrA Antibody (1C8) References:

1. Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA).  |  Kuschel, L., et al. 1999. FEBS Lett. 456: 17-21. PMID: 10452521
2. Decrease in peptide methionine sulfoxide reductase in Alzheimer's disease brain.  |  Gabbita, SP., et al. 1999. J Neurochem. 73: 1660-6. PMID: 10501213
3. Structure and mechanism of peptide methionine sulfoxide reductase, an 'anti-oxidation' enzyme.  |  Lowther, WT., et al. 2000. Biochemistry. 39: 13307-12. PMID: 11063566
4. Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals.  |  Moskovitz, J., et al. 2001. Proc Natl Acad Sci U S A. 98: 12920-5. PMID: 11606777
5. Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function.  |  Weissbach, H., et al. 2002. Arch Biochem Biophys. 397: 172-8. PMID: 11795868
6. Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues.  |  Moskovitz, J., et al. 1996. Proc Natl Acad Sci U S A. 93: 3205-8. PMID: 8622914
7. Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins.  |  Moskovitz, J., et al. 1996. Proc Natl Acad Sci U S A. 93: 2095-9. PMID: 8700890
8. Overexpression of peptide-methionine sulfoxide reductase in Saccharomyces cerevisiae and human T cells provides them with high resistance to oxidative stress.  |  Moskovitz, J., et al. 1998. Proc Natl Acad Sci U S A. 95: 14071-5. PMID: 9826655