MSP-1 Antibody (PEM-3): sc-52079

MSP-1 Antibody (PEM-3) is a mouse monoclonal IgG1 antibody that detects merozoite surface protein 1 (MSP-1) of Plasmodium falciparum by western blotting (WB). MSP-1 is a critical surface component of the blood-stage forms of the malaria-causing parasite, Plasmodium falciparum, and plays a vital role in the parasite′s invasion of red blood cells. MSP-1 undergoes selective proteolytic processing and reassembly, which is essential for merozoite attachment to and penetration of erythrocytes. MSP-1 is anchored to the parasite plasma membrane via a glycosylphosphatidylinositol (GPI) anchor, and features complex post-translational modifications, including O-linked and N-linked glycosylation, which are crucial for stability and function. These modifications enhance structural integrity and play a role in immune evasion, making MSP-1 a promising candidate for vaccine development against malaria. Anti-MSP-1 antibody (PEM-3) serves as an invaluable tool for researchers studying Plasmodium falciparum biology and malaria pathogenesis mechanisms.