MSG1 Antibody (35-W): sc-101002

MSG1 Antibody (35-W) is a mouse monoclonal IgG2a light chain antibody that detects MSG1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). MSG1, also known as CITED1, plays a crucial role in gene expression regulation, particularly in melanocyte pigmentation. MSG1 is predominantly localized in the nucleus, where MSG1 influences transcriptional activity, making MSG1 essential for maintaining melanocyte differentiation. MSG1 is expressed at high levels in strongly pigmented melanoma cells, suggesting MSG1′s involvement in pigmentation processes, while MSG1 expression diminishes in less pigmented cells, indicating a potential link to melanoma progression. The human MSG1 protein consists of 193 amino acids and exhibits 75% sequence homology with MSG1′s mouse counterpart, highlighting MSG1′s evolutionary conservation. MSG1 contains a serine/threonine-rich region, and studies have shown that a fusion protein incorporating MSG1 with a DNA-binding domain can activate transcription in mammalian cells, with this activation being dependent on MSG1′s acidic domain. This functional insight into MSG1 underscores MSG1′s importance in cellular processes and potential as a biomarker in melanoma research.

The preferred MSG1 antibody is MSG1 Antibody (D-7): sc-393585.