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MRS 3777 hemioxalate is a high affinity Adenosine A3-R antagonist (Ki = 47 nM) that displays > 200-fold selectivity versus Adenosine A1-R, Adenosine A2A-R and Adenosine A2B-R.
Perreira et al (2005) "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J.Med.Chem. 48 4910. Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247. Moro et al (2006) Progress in the pursuit of therapeutic adenosine receptor antagonists. Med.Res.Rev. 26 131.
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