Molecular structure of MRS 2578, CAS Number: 711019-86-2
MRS 2578 (CAS 711019-86-2)
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Application:
MRS 2578 is a selective P2Y66 receptor antagonist
CAS Number:
711019-86-2
Purity:
≥96%
Molecular Weight:
472.66
Molecular Formula:
C20H20N6S4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MRS 2578, a symmetric aryl diisothiocyanate derivative, is shown to be an inhibitor of P2Y6 receptors. P2Y receptors are G-coupled receptors that are ATP activated and initiate an intracellular chain of reactions. P2Y receptor activation has been reported to induce phospholipase C activity. Further studies reveal that P2Y6 receptors can cause microglial phagocytosis as well as activation of P38 MAPK and expression of COX-2 in cells exposed to UVB radiation. MRS 2578 is an inhibitor of P2Y66.
MRS 2578 (CAS 711019-86-2) References
- Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. | Mamedova, LK., et al. 2004. Biochem Pharmacol. 67: 1763-70. PMID: 15081875
- UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. | Koizumi, S., et al. 2007. Nature. 446: 1091-5. PMID: 17410128
- Involvement of P2Y6 receptor in p38 MAPK-mediated COX-2 expression in response to UVB irradiation of human keratinocytes. | Takai, E., et al. 2011. Radiat Res. 175: 358-66. PMID: 21388279
- Role of ecto-NTPDases on UDP-sensitive P2Y(6) receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women. | Noronha-Matos, JB., et al. 2012. J Cell Physiol. 227: 2694-709. PMID: 21898410
- Pharmacological characterization of uracil nucleotide-preferring P2Y receptors modulating intestinal motility: a study on mouse ileum. | Zizzo, MG., et al. 2012. Purinergic Signal. 8: 275-85. PMID: 22102167
- Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway. | Yu, W., et al. 2013. FASEB J. 27: 1895-903. PMID: 23362118
- The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction. | Hansen, A., et al. 2013. PLoS One. 8: e81491. PMID: 24278446
- Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis. | Quintas, C., et al. 2014. J Neuroinflammation. 11: 141. PMID: 25178395
- Activated microglia cause reversible apoptosis of pheochromocytoma cells, inducing their cell death by phagocytosis. | Hornik, TC., et al. 2016. J Cell Sci. 129: 65-79. PMID: 26567213
- Thymidine 5'-O-monophosphorothioate induces HeLa cell migration by activation of the P2Y6 receptor. | Gendaszewska-Darmach, E. and Szustak, M. 2016. Purinergic Signal. 12: 199-209. PMID: 26746211
- P2Y6 Receptors Regulate CXCL10 Expression and Secretion in Mouse Intestinal Epithelial Cells. | Salem, M., et al. 2018. Front Pharmacol. 9: 149. PMID: 29541027
- Characterization of UDP-Activated Purinergic Receptor P2Y₆ Involved in Japanese Flounder Paralichthys olivaceus Innate Immunity. | Li, S., et al. 2018. Int J Mol Sci. 19: PMID: 30029501
- Optogenetic activation of the distal colon epithelium engages enteric nervous system circuits to initiate motility patterns. | Najjar, SA., et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321: G426-G435. PMID: 34468219
- Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus Replication. | Mattila, S., et al. 2021. Antimicrob Agents Chemother. 65: e0139821. PMID: 34606339
Inhibitor of:
P2X5, P2Y6, and P2Y7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRS 2578, 10 mg | sc-204103 | 10 mg | $99.00 | |||
MRS 2578, 50 mg | sc-204103A | 50 mg | $390.00 |