MRS 2578, a symmetric aryl diisothiocyanate derivative, is shown to be an inhibitor of P2Y6 receptors. P2Y receptors are G-coupled receptors that are ATP activated and initiate an intracellular chain of reactions. P2Y receptor activation has been reported to induce phospholipase C activity. Further studies reveal that P2Y6 receptors can cause microglial phagocytosis as well as activation of P38 MAPK and expression of COX-2 in cells exposed to UVB radiation. MRS 2578 is an inhibitor of P2Y66.
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PMID: # 23899344 Shi, K.|Queiroz, KC.|Stap, J.|Richel, DJ.|Spek, CA.| et al. 2013. J Thromb Haemost. 11: 1892-902.