Molecular structure of MRS 2211
MRS 2211
See product citations (2)
Alternate Names:
2-[(2-Chloro-5-nitrophenyl)azo]-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde disodium salt
Application:
MRS 2211 is a competitive P2Y13 receptor antagonist
Purity:
≥96%
Molecular Weight:
474.66
Molecular Formula:
C14H10N4O8Na2PCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MRS 2211 is a selective and competitive P2Y13 receptor antagonist. Studies indicate that MRS 2211 displays greater selectivity towards P2Y1 over P2Y12 receptors. It is known that MRS 2211 inhibits ADP-induced inositol trisphosphate (IP3) formation. Research suggests that MRS 2211 inhibits phospholipase C (PLC) response to 2-methylthio-ADP in 1321N1 astrocytoma cells. P2Y receptors are important membrane proteins which function in cell-cell signaling and once activated inhibit adenylate cyclase activity. Furthermore, MRS 2211 is an essential tool in studying cell-cell signaling through the P2Y13 receptor and its effects on adenylate cyclase.
MRS 2211 References
- Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor. | Kim, YC., et al. 2005. Biochem Pharmacol. 70: 266-74. PMID: 15913566
- Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. | von Kügelgen, I. 2006. Pharmacol Ther. 110: 415-32. PMID: 16257449
- ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice. | Amisten, S., et al. 2010. Diabetologia. 53: 1927-34. PMID: 20526761
- ERK1/2 activation is involved in the neuroprotective action of P2Y13 and P2X7 receptors against glutamate excitotoxicity in cerebellar granule neurons. | Ortega, F., et al. 2011. Neuropharmacology. 61: 1210-21. PMID: 21798274
- Purinergic activation of rat skeletal muscle membranes increases Vmax and Na+ affinity of the Na,K-ATPase and phosphorylates phospholemman and α1 subunits. | Walas, H. and Juel, C. 2012. Pflugers Arch. 463: 319-26. PMID: 22057585
- Involvement of P2Y13 receptor in suppression of neuronal differentiation. | Yano, S., et al. 2012. Neurosci Lett. 518: 5-9. PMID: 22521313
- Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes. | Balduini, A., et al. 2012. Haematologica. 97: 1657-65. PMID: 22689668
- Prasugrel metabolites inhibit neutrophil functions. | Liverani, E., et al. 2013. J Pharmacol Exp Ther. 344: 231-43. PMID: 23097214
- The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss. | Voss, U., et al. 2014. Purinergic Signal. 10: 455-64. PMID: 24510452
- Nucleotide P2Y13-stimulated phosphorylation of CREB is required for ADP-induced proliferation of late developing retinal glial progenitors in culture. | Jacques, FJ., et al. 2017. Cell Signal. 35: 95-106. PMID: 28347874
- Activation of spinal dorsal horn P2Y13 receptors can promote the expression of IL-1β and IL-6 in rats with diabetic neuropathic pain. | Zhou, R., et al. 2018. J Pain Res. 11: 615-628. PMID: 29628771
- Microglia P2Y13 Receptors Prevent Astrocyte Proliferation Mediated by P2Y1 Receptors. | Quintas, C., et al. 2018. Front Pharmacol. 9: 418. PMID: 29773988
- P2Y13 and P2X7 receptors modulate mechanically induced adenosine triphosphate release from mast cells. | Shen, D., et al. 2020. Exp Dermatol. 29: 499-508. PMID: 32155290
- Erythrocytes from patients with ST-elevation myocardial infarction induce cardioprotection through the purinergic P2Y13 receptor and nitric oxide signaling. | Jiao, T., et al. 2022. Basic Res Cardiol. 117: 46. PMID: 36112326
- Extracellular adenosine 5'-diphosphate promotes MCP-1/CCL2 expression via the P2Y13 purinergic receptor/ERK signaling axis in temporomandibular joint-derived mouse fibroblast-like synoviocytes. | Yokota, S., et al. 2023. Mol Biol Rep. 50: 1595-1602. PMID: 36526849
Inhibitor of:
P2Y13.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRS 2211, 10 mg | sc-204101 | 10 mg | $116.00 | |||
MRS 2211, 50 mg | sc-204101A | 50 mg | $454.00 |