Date published: 2025-9-25

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MRS 1754 (CAS 264622-58-4)

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CAS Number:
264622-58-4
Molecular Weight:
486.52
Molecular Formula:
C26H26N6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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MRS 1754, also known as NCP-2-DP, is a synthetic molecule utilized across various laboratory and scientific research applications. This compound has been recognized for its range of biological activities and has been the subject of in vitro research efforts. The primary interest in MRS 1754 lies in its potential to inhibit key enzymes that play a role in cell signaling pathways. Research has demonstrated that MRS 1754 can interrupt the function of enzymes such as phospholipase A2, protein kinase C, and cyclooxygenase-2, which are pivotal in the regulation of biological processes. This inhibitory action is thought to be the reason behind the molecule′s biological activities observed in experimental studies.


MRS 1754 (CAS 264622-58-4) References

  1. Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor.  |  Liou, GI., et al. 2008. Invest Ophthalmol Vis Sci. 49: 5526-31. PMID: 18641283
  2. Regulation of serotonin transporter activity by adenosine in intestinal epithelial cells.  |  Matheus, N., et al. 2009. Biochem Pharmacol. 78: 1198-204. PMID: 19539610
  3. Up-regulation of vascular endothelial growth factor expression by adenosine through adenosine A2 receptors in the rat tongue treated with endotoxin.  |  Hara, Y., et al. 2009. Arch Oral Biol. 54: 932-42. PMID: 19712927
  4. Adenosine A₂A and A₃ receptors are involved in the human endothelial progenitor cells migration.  |  Fernandez, P., et al. 2012. J Cardiovasc Pharmacol. 59: 397-404. PMID: 22217884
  5. The stimulatory adenosine receptor ADORA2B regulates serotonin (5-HT) synthesis and release in oxygen-depleted EC cells in inflammatory bowel disease.  |  Dammen, R., et al. 2013. PLoS One. 8: e62607. PMID: 23638125
  6. ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy.  |  Elsherbiny, NM., et al. 2013. Life Sci. 93: 78-88. PMID: 23770229
  7. Adenosine A2B receptors induce proliferation, invasion and activation of cAMP response element binding protein (CREB) in trophoblast cells.  |  Darashchonak, N., et al. 2014. BMC Pregnancy Childbirth. 14: 2. PMID: 24383849
  8. Activation of adenosine A2B receptor impairs properties of trophoblast cells and involves mitogen-activated protein (MAP) kinase signaling.  |  Darashchonak, N., et al. 2014. Placenta. 35: 763-71. PMID: 25002363
  9. Regulation of protein kinase C-epsilon and its age-dependence.  |  Kang, C., et al. 2017. Biochem Biophys Res Commun. 482: 1201-1206. PMID: 27919679
  10. IL-27 regulates HIF-1α-mediated VEGFA response in macrophages of diabetic retinopathy patients and healthy individuals.  |  Zhang, Q., et al. 2019. Cytokine. 113: 238-247. PMID: 30007476
  11. Adenosine receptor Adora2b antagonism attenuates Brucella abortus 544 infection in professional phagocyte RAW 264.7 cells and BALB/c mice.  |  Reyes, AWB., et al. 2020. Vet Microbiol. 242: 108586. PMID: 32122590

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

MRS 1754, 5 mg

sc-301174
5 mg
$210.00

MRS 1754, 25 mg

sc-301174A
25 mg
$818.00