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MRS 1523 (CAS 212329-37-8)

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Alternate Names:
3-Propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate
Application:
MRS 1523 is a selective A3 adenosine receptor antagonist in the rat
CAS Number:
212329-37-8
Molecular Weight:
399.55
Molecular Formula:
C23H29NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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MRS 1523 is a selective and potent antagonist of the P2Y1 receptor, which is a G protein-coupled receptor for ADP. It functions by competitively inhibiting the binding of ADP to the P2Y1 receptor, thereby blocking downstream signaling pathways mediated by this receptor. Mrs 1523′s mechanism of action involves targeting the P2Y1 receptor and preventing its activation by ADP, thereby interfering with intracellular calcium mobilization and other cellular responses mediated by this receptor. By blocking the P2Y1 receptor, MRS 1523 can modulate platelet aggregation, vascular smooth muscle contraction, and other physiological processes regulated by this receptor. Mrs 1523′s functional role in experimental applications involves studying the specific effects of P2Y1 receptor antagonism on cellular and physiological processes, providing insights into the role of this receptor in various biological pathways.


MRS 1523 (CAS 212329-37-8) References

  1. Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model.  |  Fan, M., et al. 2003. Am J Physiol Lung Cell Mol Physiol. 284: L1012-9. PMID: 12533441
  2. Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine.  |  Kin, H., et al. 2005. Cardiovasc Res. 67: 124-33. PMID: 15949476
  3. Cl-IB-MECA inhibits human thyroid cancer cell proliferation independently of A3 adenosine receptor activation.  |  Morello, S., et al. 2008. Cancer Biol Ther. 7: 278-84. PMID: 18059189
  4. Stimulation of the adenosine A3 receptor reverses vascular hyporeactivity after hemorrhagic shock in rats.  |  Zhou, R., et al. 2010. Acta Pharmacol Sin. 31: 413-20. PMID: 20348945
  5. P-glycoprotein mediates resistance to A3 adenosine receptor agonist 2-chloro-N6-(3-iodobenzyl)-adenosine-5'-n-methyluronamide in human leukemia cells.  |  Mlejnek, P., et al. 2012. J Cell Physiol. 227: 676-85. PMID: 21520073
  6. Hide and seek: a comparative autoradiographic in vitro investigation of the adenosine A3 receptor.  |  Haeusler, D., et al. 2015. Eur J Nucl Med Mol Imaging. 42: 928-39. PMID: 25739834
  7. Adenosine A3 receptor activation inhibits pronociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons.  |  Coppi, E., et al. 2019. Pain. 160: 1103-1118. PMID: 31008816
  8. LJ529 attenuates mast cell-related inflammation via A3R-PKCε-ALDH2 pathway after subarachnoid hemorrhage in rats.  |  Zhang, T., et al. 2021. Exp Neurol. 340: 113686. PMID: 33713658
  9. Adenosine receptor antagonists: Recent advances and therapeutic perspective.  |  Saini, A., et al. 2022. Eur J Med Chem. 227: 113907. PMID: 34695776
  10. Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists.  |  Gao, ZG., et al. 2021. Purinergic Signal. 17: 737-746. PMID: 34713378
  11. Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities.  |  Lauro, F., et al. 2022. Cell Mol Neurobiol. 42: 2909-2918. PMID: 34773542
  12. A3 adenosine receptor agonist IB-MECA reverses chronic cerebral ischemia-induced inhibitory avoidance memory deficit.  |  Cheng, P., et al. 2022. Eur J Pharmacol. 921: 174874. PMID: 35278404
  13. Therapeutic Potential of Highly Selective A3 Adenosine Receptor Ligands in the Central and Peripheral Nervous System.  |  Coppi, E., et al. 2022. Molecules. 27: PMID: 35335254

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

MRS 1523, 5 mg

sc-253057
5 mg
$254.00

MRS 1523, 25 mg

sc-253057A
25 mg
$978.00

What is the solubility of MRS 1523 (CAS 212329-37-8) in ethanol? Do you have the partion coefficient (oil/water) for this compound?

Asked by: Rafi
Thank you for your question. Unfortunately we do not have information on the partition coefficient or for solubility in ethanol.
Answered by: Tech Service
Date published: 2019-11-12
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Rated 5 out of 5 by from Alnouri MW; et alAlnouri MW; et al. (PubMed ID: 26126429) determined that MRS 1523 is a selective A3AR antagonist in human and rat, but only moderately selective in mouse. -SCBT Publication Review
Date published: 2015-04-03
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MRS 1523 is rated 5.0 out of 5 by 1.
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