MRP-L28 Antibody (A-10): sc-390714

MRP-L28 Antibody (A-10) is a mouse monoclonal IgM antibody that detects MRP-L28 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MRP-L28 antibody (A-10) is available as the non-conjugated form. MRP-L28, also known as 39S ribosomal protein L28 and melanoma-associated antigen recognized by T lymphocytes, plays a crucial role in mitochondrial function as a component of the mitochondrial ribosome, which is essential for protein synthesis within mitochondria. MRP-L28 is vital for cellular respiration and energy production, impacting overall cell metabolism and function. MRP-L28 is recognized by tumor-infiltrating lymphocytes (TIL) 1290, making MRP-L28 a potential therapeutic target for patients with the HLA-A24 serotype, which is prevalent in various populations, including those from Austronesia and indigenous groups in Taiwan and Greenland. MRP-L28 is expressed in a range of normal tissues, including the spleen, testis, thymus, liver, kidney, brain, adrenal glands, lungs, and retinal tissue, highlighting MRP-L28′s significance in both normal physiology and potential pathological conditions.

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MRP-L28 Antibody (A-10) References:

1. Recognition of shared melanoma antigens in association with major HLA-A alleles by tumor infiltrating T lymphocytes from 123 patients with melanoma.  |  Kawakami, Y., et al. 2000. J Immunother. 23: 17-27. PMID: 10687134
2. Gene order evolution and paleopolyploidy in hemiascomycete yeasts.  |  Wong, S., et al. 2002. Proc Natl Acad Sci U S A. 99: 9272-7. PMID: 12093907
3. Genomic differences between Candida glabrata and Saccharomyces cerevisiae around the MRPL28 and GCN3 loci.  |  Walsh, DW., et al. 2002. Yeast. 19: 991-4. PMID: 12125055
4. Identification of new immunogenic peptides in conserved regions of hepatitis C virus (HCV) 1b with the potentiality to generate cytotoxic T lymphocytes in HCV1b(+) HLA-A24(+) patients.  |  Takao, Y., et al. 2007. Hepatol Res. 37: 186-95. PMID: 17362301
5. Identification of human leukocyte antigen-A24-restricted epitope peptides derived from gene products upregulated in lung and esophageal cancers as novel targets for immunotherapy.  |  Suda, T., et al. 2007. Cancer Sci. 98: 1803-8. PMID: 17784873
6. Lung tissue and tumour-infiltrating T lymphocytes in patients with non-small cell lung carcinoma and chronic obstructive pulmonary disease (COPD): moderate/severe versus mild stage of COPD.  |  Marc, MM., et al. 2007. Scand J Immunol. 66: 694-702. PMID: 17949407
7. Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes.  |  Robbins, PF., et al. 1995. J Immunol. 154: 5944-50. PMID: 7751637
8. A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes.  |  Robbins, PF., et al. 1996. J Exp Med. 183: 1185-92. PMID: 8642260

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MRP-L28 Antibody (A-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MRP-L28 Antibody (A-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MRP-L28 Antibody (A-10) Specifications

Alternate Product Name: MRP-L28

Product Clone Name: A-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 17-40

Epitope Target: MRP-L28

Epitope Species: human

Product Reactivity/Detection: MRP-L28

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MRP-L28 Antibody (A-10): P: Blocking Peptide