mrnp41 Antibody (G-3): sc-393625

mrnp41 Antibody (G-3) is a mouse monoclonal IgG3 antibody that detects mrnp41 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). mrnp41 (Rae1 protein homolog) is a 368 amino acid protein that plays a crucial role in the nucleocytoplasmic transport of mRNA, primarily localizing to the nuclear pore complex within the nuclear envelope. This localization facilitates the export of mRNA from the nucleus to the cytoplasm, a vital process for gene expression regulation. Mutations in mrnp41 can lead to the accumulation of poly(A)-containing mRNA in the nucleus, underscoring mrnp41′s essential function as a primary nuclear exporter of mRNA. Additionally, mrnp41 interacts with Nup98 to regulate E-cadherin, an important component of the anaphase-promoting complex, which helps prevent securin degradation, suggesting a potential role in maintaining euploidy. During mitosis, mrnp41 is required alongside NuMA for bipolar spindle formation, highlighting mrnp41′s importance in cell division. With versatile applications and critical biological functions, anti-mrnp41 antibody (G-3) serves as an invaluable tool for researchers studying mRNA transport and cellular processes.

The preferred mrnp41 antibody is mrnp41 Antibody (A-12): sc-374261.