mpV(pic)
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mpV(pic) is a protein Cdc25C (phosphotyrosine phosphatase) inhibitor and insulin receptor kinase (IRK) activator. mpV(pic) displays a distinct preference for dephosphorylating the insulin receptor rather than the epidermal growth factor receptor (EGFR). It promotes glycogen synthesis. mpV(pic) also functions as a tyrosine phosphatase inhibitor, influencing the regulatory mechanisms of cell volume in Ehrlich ascites tumor cells (EATC) through its effect on the TASK-2 channel. It shifts the volume set point for the inactivation of TASK-2 to a lower cell volume, thereby affecting the swelling-activated K(+) efflux. mpV(pic) enhances the volume-sensitive part of the K(+) efflux, playing a role in the regulation of cell volume decrease following hypotonic exposure, which is an essential cellular process indicating mpV(pic)′s potential in modulating ion channel activity and cell volume regulation mechanisms.
mpV(pic) References
- Protein phosphotyrosine phosphatase inhibitors suppress regulatory volume decrease and the volume-sensitive Cl- conductance in mouse fibroblasts. | Thoroed, SM., et al. 1999. Pflugers Arch. 438: 133-40. PMID: 10370098
- Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity. | Bartsch, O., et al. 2001. Mol Hum Reprod. 7: 799-809. PMID: 11517286
- Enzyme assays by fluorescence polarization in the presence of polyarginine: study of kinase, phosphatase, and protease reactions. | Simeonov, A., et al. 2002. Anal Biochem. 304: 193-9. PMID: 12009695
- Characterization of an ecto-phosphatase activity in the human parasite Trichomonas vaginalis. | de Jesus, JB., et al. 2002. Parasitol Res. 88: 991-7. PMID: 12375165
- Characterization of an ecto-phosphatase activity in malpighian tubules of hematophagous bug Rhodnius prolixus. | Ferraro, RB., et al. 2004. Arch Insect Biochem Physiol. 57: 40-9. PMID: 15352154
- Entamoeba histolytica: an ecto-phosphatase activity regulated by oxidation-reduction reactions. | de Sá Pinheiro, AA., et al. 2007. Exp Parasitol. 115: 352-8. PMID: 17113080
- Protein-tyrosine phosphatase activity maintains the viability of hairy cells and modulates their response to interferon-alpha. | Allsup, D., et al. 2008. Leuk Lymphoma. 49: 2351-8. PMID: 19052984
- Activation of the TASK-2 channel after cell swelling is dependent on tyrosine phosphorylation. | Kirkegaard, SS., et al. 2010. Am J Physiol Cell Physiol. 299: C844-53. PMID: 20631251
- LCK is an important mediator of B-cell receptor signaling in chronic lymphocytic leukemia cells. | Talab, F., et al. 2013. Mol Cancer Res. 11: 541-54. PMID: 23505068
- Bombyxin-stimulated ecdysteroidogenesis in relation to sugar transporter/trehalase expressions in Bombyx prothoracic glands. | Gu, SH., et al. 2022. Insect Biochem Mol Biol. 151: 103864. PMID: 36336193
- Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB rats. | Yale, JF., et al. 1995. Diabetes. 44: 1274-9. PMID: 7589823
- In vivo insulin mimetic effects of pV compounds: role for tissue targeting in determining potency. | Bevan, AP., et al. 1995. Am J Physiol. 268: E60-6. PMID: 7840184
- Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. | Posner, BI., et al. 1994. J Biol Chem. 269: 4596-604. PMID: 8308031
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
mpV(pic), 10 mg | sc-221958 | 10 mg | $257.00 | |||
mpV(pic), 50 mg | sc-221958A | 50 mg | $1151.00 |