MPPED1 Antibody (D-2): sc-398972

MPPED1 Antibody (D-2) is a mouse monoclonal IgM antibody that detects MPPED1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MPPED1 antibody (D-2) is available as the non-conjugated form. MPPED1, or metallophosphoesterase domain containing 1, is a 326 amino acid protein predominantly expressed in the adult brain, where MPPED1 plays a crucial role in the development and function of the central nervous system. MPPED1 is believed to be involved in various cellular processes, including the regulation of phosphoesterase activity, which is essential for maintaining cellular homeostasis and signaling pathways. The gene encoding MPPED1 is located on human chromosome 22, a region associated with several genetic disorders, including Phelan-McDermid syndrome and neurofibromatosis type 2. Notably, mutations in genes on this chromosome can lead to significant neurological and psychiatric conditions, highlighting the importance of MPPED1 in both health and disease. Additionally, MPPED1′s presence in the brain suggests potential involvement in neurodevelopmental processes, making MPPED1 a valuable target for research into neurological disorders.

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MPPED1 Antibody (D-2) References:

1. Chromosome 22 workshop report.  |  Schwab, SG. and Wildenauer, DB. 1999. Am J Med Genet. 88: 276-8. PMID: 10374745
2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.  |  Matsuda, A., et al. 2003. Oncogene. 22: 3307-18. PMID: 12761501
3. Constitutional rearrangements of chromosome 22 as a cause of neurofibromatosis 2.  |  Tsilchorozidou, T., et al. 2004. J Med Genet. 41: 529-34. PMID: 15235024
4. Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome.  |  Paylor, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 7729-34. PMID: 16684884
5. Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia.  |  Arinami, T. 2006. J Hum Genet. 51: 1037-1045. PMID: 16969581
6. Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings.  |  Ahronowitz, I., et al. 2007. Hum Mutat. 28: 1-12. PMID: 16983642
7. Deletion 22q11: spectrum of associated disorders.  |  Hay, BN. 2007. Semin Pediatr Neurol. 14: 136-9. PMID: 17980310
8. The 239AB gene on chromosome 22: a novel member of an ancient gene family.  |  Schwartz, F. and Ota, T. 1997. Gene. 194: 57-62. PMID: 9266672

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MPPED1 Antibody (D-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MPPED1 Antibody (D-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MPPED1 Antibody (D-2) Specifications

Alternate Product Name: MPPED1

Product Clone Name: D-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 74-92

Epitope Target: MPPED1

Epitope Species: human

Product Reactivity/Detection: MPPED1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MPPED1 Antibody (D-2): P: Blocking Peptide