Molecular structure of MPP+ iodide, CAS Number: 36913-39-0
MPP+ iodide (CAS 36913-39-0)
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Alternate Names:
1-Methyl-4-phenylpyridinium iodide
Application:
MPP+ iodide is an active metabolite of the dopaminergic neurotoxin MPTP
CAS Number:
36913-39-0
Purity:
≥98%
Molecular Weight:
297.14
Molecular Formula:
C12H12IN
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MPP+ iodide is a metabolite of dopaminergic neurotoxin MPTP which stimulates the production of the superoxide radical resulting in apoptosis in PC12 cells. Studies suggest that MPP+ iodide is a selective inhibitor of mitochondrial complex I and it decreases mitochondrial REDOX activity. In addition, GSK-3beta is a mediator of MPP+ iodide induced neurotoxicity. Alternate studies indicate that the D-loop of human mtDNA is destabilized by MPP+ iodide via releasing the nascent H-strands of mtDNA.
MPP+ iodide (CAS 36913-39-0) References
- The D-loop structure of human mtDNA is destabilized directly by 1-methyl-4-phenylpyridinium ion (MPP+), a parkinsonism-causing toxin. | Umeda, S., et al. 2000. Eur J Biochem. 267: 200-6. PMID: 10601867
- Non-linear effects of cycloheximide in glutamate-treated cultured rat cerebellar neurons. | Marotta, D., et al. 2002. Neurotoxicology. 23: 307-12. PMID: 12387359
- 1-methyl-4-phenylpyridinium (MPP+) decreases mitochondrial oxidation-reduction (REDOX) activity and membrane potential (Deltapsi(m)) in rat striatum. | Nakai, M., et al. 2003. Exp Neurol. 179: 103-10. PMID: 12504872
- Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells. | Molina-Holgado, F., et al. 2008. J Neurochem. 105: 2466-76. PMID: 18331585
- Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. | Hu, X., et al. 2008. J Immunol. 181: 7194-204. PMID: 18981141
- Mechanistic aspects of 1-methyl-4-phenyl pyridinium iodide toxicity in Escherichia coli: the role of oxygen and hydrogen peroxide. | Haskel, Y., et al. 1991. Isr J Med Sci. 27: 207-12. PMID: 1901301
- Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neurons. | Petit-Paitel, A., et al. 2009. PLoS One. 4: e5491. PMID: 19430525
- Hydrogen sulfide inhibits MPP(+)-induced apoptosis in PC12 cells. | Yin, WL., et al. 2009. Life Sci. 85: 269-75. PMID: 19540852
- Lycopene protects against MPP(+)-induced cytotoxicity by maintaining mitochondrial function in SH-SY5Y cells. | Yi, F., et al. 2013. Neurochem Res. 38: 1747-57. PMID: 23709364
- UNC-51-like kinase 1 blocks S6k1 phosphorylation contributes to neurodegeneration in Parkinson's disease model in vitro. | Li, Y., et al. 2015. Biochem Biophys Res Commun. 459: 196-200. PMID: 25680463
- miR-124-3p attenuates MPP+-induced neuronal injury by targeting STAT3 in SH-SY5Y cells. | Geng, L., et al. 2017. Exp Biol Med (Maywood). 242: 1757-1764. PMID: 28958159
- Differential effect of Ayurvedic nootropics on C. elegans models of Parkinson's disease. | Anjaneyulu, J., et al. 2020. J Ayurveda Integr Med. 11: 440-447. PMID: 32978047
- Mitochondrial dysfunction and apoptosis are attenuated through activation of AMPK/GSK-3β/PP2A pathway in Parkinson's disease. | Su, J., et al. 2021. Eur J Pharmacol. 907: 174202. PMID: 34048739
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MPP+ iodide, 100 mg | sc-255309 | 100 mg | $140.00 |