Molecular structure of MPP dihydrochloride, CAS Number: 289726-02-9
MPP dihydrochloride (CAS 289726-02-9)
See product citations (13)
Alternate Names:
1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride
Application:
MPP dihydrochloride is a high affinity silent antagonist at ERα
CAS Number:
289726-02-9
Molecular Weight:
542.50
Molecular Formula:
C29H31N3O3•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MPP dihydrochloride is a selective, high affinity silent antagonist at ERalpha. Displays greater than 200-fold selectivity for ERalpha over ERbeta. Ki values are 2.7 and 1800 nM at ERalpha and ERbeta respectively
MPP dihydrochloride (CAS 289726-02-9) References
- Estrogen provides neuroprotection against activated microglia-induced dopaminergic neuronal injury through both estrogen receptor-alpha and estrogen receptor-beta in microglia. | Liu, X., et al. 2005. J Neurosci Res. 81: 653-65. PMID: 16013043
- ER-β mediates 17β-estradiol attenuation of HIV-1 Tat-induced apoptotic signaling. | Adams, SM., et al. 2010. Synapse. 64: 829-38. PMID: 20340172
- Estrogen dependent signaling in reproductive tissues - a role for estrogen receptors and estrogen related receptors. | Gibson, DA. and Saunders, PT. 2012. Mol Cell Endocrinol. 348: 361-72. PMID: 21964318
- Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha. | Mosquera, L., et al. 2014. Brain Res. 1561: 11-22. PMID: 24637260
- Estrogen Activates AMP-Activated Protein Kinase in Human Endothelial Cells via ERβ/Ca(2+)/Calmodulin-Dependent Protein Kinase Kinase β Pathway. | Yang, S. and Wang, J. 2015. Cell Biochem Biophys. 72: 701-7. PMID: 25616441
- Estrogen receptors and estetrol-dependent neuroprotective actions: a pilot study. | Tskitishvili, E., et al. 2017. J Endocrinol. 232: 85-95. PMID: 27799463
- Rapid estrogen receptor-α signaling mediated by ERK activation regulates vascular tone in male and ovary-intact female mice. | Kim, SC., et al. 2018. Am J Physiol Heart Circ Physiol. 314: H330-H342. PMID: 28887333
- The ginsenoside PPD exerts anti-endometriosis effects by suppressing estrogen receptor-mediated inhibition of endometrial stromal cell autophagy and NK cell cytotoxicity. | Zhang, B., et al. 2018. Cell Death Dis. 9: 574. PMID: 29760378
- α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167). | Karaboğa Arslan, AK. and Yerer, MB. 2018. Nutrients. 10: PMID: 29799481
- Effects of low-magnitude high-frequency vibration on osteoblasts are dependent on estrogen receptor α signaling and cytoskeletal remodeling. | Haffner-Luntzer, M., et al. 2018. Biochem Biophys Res Commun. 503: 2678-2684. PMID: 30093109
- Molecular docking of genistein on estrogen receptors, promoter region of BCLX, caspase-3, Ki-67, cyclin D1, and telomere activity. | Yuseran, H., et al. 2019. J Taibah Univ Med Sci. 14: 79-87. PMID: 31435394
- Estrogen enhances browning in adipose tissue by M2 macrophage polarization via heme oxygenase-1. | Sul, OJ., et al. 2021. J Cell Physiol. 236: 1875-1888. PMID: 32716106
Inhibitor of:
DAX-1.Activator of:
ERRα.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MPP dihydrochloride, 10 mg | sc-204098 | 10 mg | $184.00 | |||
MPP dihydrochloride, 50 mg | sc-204098A | 50 mg | $744.00 |