MPP dihydrochloride CAS: 289726-02-9
MF: C29H31N3O3•2HCl
MW: 542.50
A high affinity silent antagonist at ERα.

MPP dihydrochloride (CAS 289726-02-9)

MPP dihydrochloride | CAS 289726-02-9 is rated 5.0 out of 5 by 1.
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Synonym: 1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride
Application: A high affinity silent antagonist at ERα
CAS Number: 289726-02-9
Molecular Weight: 542.50
Molecular Formula: C29H31N3O32HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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MPP dihydrochloride is a selective, high affinity silent antagonist at ERα. Displays greater than 200-fold selectivity for ERα over ERβ. Ki values are 2.7 and 1800 nM at ERα and ERβ respectively.


References

Sun et al (2002) Antagonists selective for estrogen receptor a. Endocrinol. 143 941. Harrington et al (2003) Activities of estrogen receptor alpha- and beta-selective ligands at diverse responsive gene sites mediating transactivation or transrepression. Mol.Cell.Endocrinol. 206 13.

Physical State :
Solid
Solubility :
Soluble in water (5 mM, with gentle warming), ethanol (25 mM), and DMSO (100 mM).
Storage :
Store at room temperature
Refractive Index :
n20D 1.64 (Predicted)
Ki Data :
ERα: Ki= 2.7 nM; ERβ: Ki= 1.8 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
45073474
MDL Number :
MFCD06411603
SMILES :
CC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)OCCN5CCCCC5.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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MPP dihydrochloride  Product Citations

See how others have used MPP dihydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 29352507  Xing, FZ.|Zhao, YG.|Zhang, YY.|He, L.|Zhao, JK.|Liu, MY.|Liu, Y.|Zhang, JQ.| et al. 2018. CNS Neurosci Ther. 24: 495-507.

PMID: # 29495557  Kowalska, K. et al. 2018. Toxins (Basel). 10:

PMID: # 30356713  Gu, Y.|Wu, Y.|Su, W.|Xing, L.|Shen, Y.|He, X.|Li, L.|Yuan, Y.|Tang, X.|Chen, G.| et al. 2018. Front Pharmacol. 9: 1026.

PMID: # 28267258  Herz, C.|Tran, HTT.|Landerer, S.|Gaus, J.|Schlotz, N.|Lehr, L.|Schäfer, WR.|Treeck, O.|Odongo, GA.|Skatchkov, I.|Lamy, E.| et al. 2017. Mol Nutr Food Res. 61:

PMID: # 28789972  Zhao, Y. et al. 2017. J. Steroid Biochem. Mol. Biol. 174: 96-113.

PMID: # 25323043  Wang, YC. et al. 2015. British journal of pharmacology. 172: 5586-95.

PMID: # 24938798  Li, J. et al. 2014. Theriogenology. 82: 517-24.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from Chan et al Chan et al. (PubMed ID 24819599) found that MPP suppressed ovarian cancer growth by blocking Estrogen receptor alpha.
Date published: 2015-04-20
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