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MOZ Antibody (4D8) - Western Blotting - Image 367978
MOZ 抗体 (4D8): sc-293283. Jurkat (A) 和 RT-4 (B) 全细胞裂解液中 MOZ 表达的 Western 印迹分析.
MOZ Antibody (4D8) - Western Blotting - Image 367978
MOZ 抗体 (4D8): sc-293283. Jurkat (A) 和 RT-4 (B) 全细胞裂解液中 MOZ 表达的 Western 印迹分析.
MOZ Antibody (4D8) - Immunohistochemistry - Image 346128
MOZ 抗体 (4D8): sc-293283. 福尔马林固定, 石蜡包埋的人类胎盘组织的免疫过氧化物酶染色, 显示核染色.
MOZ Antibody (4D8) - Western Blotting - Image 348888
MOZ 抗体 (4D8): sc-293283. 人重组 MOZ 融合蛋白的 Western 印迹分析.
MOZ 抗体 (4D8): sc-293283. Jurkat (A) 和 RT-4 (B) 全细胞裂解液中 MOZ 表达的 Western 印迹分析.

MOZ 抗体 (4D8): sc-293283

4.7(3)
寫評論提問

说明书
  • MOZ 抗体 4D8 是小鼠单克隆 IgG2b (kappa轻链)，MOZ抗体，规格为100 µg/ml
  • 针对部分重组蛋白，其氨基酸序列在MOZ的human起源的81-179范围内
  • 推荐用于 human 来源的MOZ WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取MOZ (4D8): sc-293283的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG2b BP-HRP 是MOZ 抗体 (4D8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与MOZ 抗体 (4D8) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

MOZ抗体（4D8）是一种小鼠单克隆IgG2b kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和酶联免疫吸附测定（ELISA）检测人类源性MOZ蛋白。抗MOZ抗体（4D8）可作为非结合型同种型抗体使用。MOZ蛋白，又称单核细胞白血病锌指蛋白，作为染色质相关组蛋白乙酰转移酶（HAT）在染色质重塑和转录调控中发挥着至关重要的作用。MOZ（4D8）单克隆抗体可促进组蛋白的乙酰化，从而形成更开放的染色质结构，使转录机制能够接触到DNA。MOZ蛋白与急性髓细胞性白血病有关，因为其参与变异易位，导致MOZ融合蛋白的形成，从而通过改变组蛋白乙酰化异常增强转录激活。MOZ (4D8)抗体与其他蛋白质相互作用，如MORF（MOZ相关因子）和Tip60，两者在转录调控中具有显著的结构相似性和功能作用。MORF 同时具有 HAT 活性和转录抑制能力，而 Tip60 则以其作为各种核激素受体的共激活因子而闻名，这进一步强调了 MOZ 蛋白在细胞过程中的重要性及其在癌症生物学中的潜在意义。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MOZ 抗体 (4D8) 参考文献:

  1. Tip60 是一种核激素受体辅激活剂。  |  Brady, ME., et al. 1999. J Biol Chem. 274: 17599-604. PMID: 10364196
  2. 鉴定与单核细胞白血病锌指蛋白有关的人类组蛋白乙酰转移酶。  |  Champagne, N., et al. 1999. J Biol Chem. 274: 28528-36. PMID: 10497217
  3. MOZ/MLL介导的转录激活系统在正常造血和白血病发生中的自我更新作用。  |  Yokoyama, A. 2022. FEBS J. 289: 7987-8002. PMID: 34482632
  4. MOZ/KAT6A在血液系统恶性肿瘤中的作用以及MOZ/KAT6A抑制剂的发展。  |  Su, J., et al. 2021. Pharmacol Res. 174: 105930. PMID: 34626770
  5. MOZ和Menin-MLL复合物是胃肠道间质瘤中染色质结合和转录输出的互补调节因子。  |  Hemming, ML., et al. 2022. Cancer Discov. 12: 1804-1823. PMID: 35499757
  6. MOZ通过调节Hoxa9/Meis1的表达，对MOZ/MLL融合引起的白血病的发展至关重要。  |  Katsumoto, T., et al. 2022. Blood Adv. 6: 5527-5537. PMID: 35947126
  7. 急性髓性白血病的 t(8;16)(p11;p13)易位将一个假定的乙酰转移酶与 CREB 结合蛋白融合在一起。  |  Borrow, J., et al. 1996. Nat Genet. 14: 33-41. PMID: 8782817
  8. mof是一种推测的乙酰转移酶基因，与人类的Tip60和MOZ基因以及酵母的SAS基因有关，是果蝇体内剂量补偿所必需的。  |  Hilfiker, A., et al. 1997. EMBO J. 16: 2054-60. PMID: 9155031
  9. 白血病中染色体 8p11 带的异常：根据 MOZ 受累情况可区分两种临床综合征。  |  Aguiar, RC., et al. 1997. Blood. 90: 3130-5. PMID: 9376594
  10. HIV-1-Tat 交互蛋白 Tip60 的组蛋白乙酰转移酶活性的新底物特异性。  |  Yamamoto, T. and Horikoshi, M. 1997. J Biol Chem. 272: 30595-8. PMID: 9388189
  11. 急性髓性白血病中 MOZ 与核受体辅助激活因子 TIF2 之间的新型融合。  |  Carapeti, M., et al. 1998. Blood. 91: 3127-33. PMID: 9558366
  12. 组蛋白乙酰转移酶和去乙酰化酶在基因调控中的作用。  |  Kuo, MH. and Allis, CD. 1998. Bioessays. 20: 615-26. PMID: 9780836

订购信息

产品名称产品编号规格价格数量收藏夹

MOZ 抗体 (4D8)

sc-293283
100 µg/ml
$316.00

MOZ (4D8): m-IgG2b BP-HRP 套装

sc-548547
100 µg Ab; 10 µg BP
$354.00

Hello, can this antibody (MOZ Antibody: sc-293283) be able to react with the mouse sample?

Asked by: LYQ2019
Thank you for your question. This antibody has not yet been tested in mouse and so that is not a recommended species at this time. We are still gathering data to show on our website. Check back for updates!
Answered by: Tech Service
Date published: 2019-09-25

Can sc-293283: MOZ (4D8) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Professor Griffin
Thank you for your question. Yes, sc-293283: MOZ (4D8) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24

Hello. Is this antibody available as a sample? I am looking for a good MOZ antibody.

Asked by: Master Wendu
Thank you for your question. Yes, for a limited time we are currently offer a free 10 µg sample of our mouse monoclonal MOZ Antibody (4D8): sc-293283. Please contact our Technical Service Department if you would like to request that a sample be shipped to your lab. Please call us toll-free at (800) 457-3801 option 2, email scbt@scbt.com, or use the live chat on our website.
Answered by: Technical Support
Date published: 2017-02-13
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Rated 5 out of 5 by from Good for Western BlotAntibody detects human MOZ in Jurkat and RT-4 cell lysates by Western blot. -SCBT QC
Date published: 2023-09-14
Rated 4 out of 5 by from 不错的抗体我在一个多月前申请了该抗体小样进行了试验，在HCC细胞系SMMC-7721和Huh7细胞中进行了WB验证，抗体本身是没问题的，可以杂出比较好的结果，十分感谢。
Date published: 2017-12-13
Rated 5 out of 5 by from Western blot analysis of MOZ protein in SK-Hep1All lanes : MOZ 抗体 (4D8): sc-293283 at 0.5 µg/ml Lane 1 : SK-Hep1 (Human hepatocellular carcinoma cell line) Lysate Lane 2 : SK-Hep1 (Human hepatocellular carcinoma cell line) Lysate treated with siRNA Lysates/proteins at 80,000 cells per lane. Lysis buffer used: SDS Sample Buffer Reducing agent: DTT Lysate Preparation:sample boiled at 100℃ for 10min Predicted band size : 231 kDa Observed band size : a band larger than 170 kDa,but we are unsure whether the band is correct because we have no marker larger than 170 kDa. Electrophoresis: Gel Percentage:8% Electrophoresis Conditions:1X Tris-Gycine running buffer Time: 2h in 100V Membrane Transfer: Method:Wet Transfer Transfer buffer: 25 mM Tris-base, 0.2 M Gycine, 20% Methanol, pH 8.5 Membrane Type: PVDF Time: overnight at 4℃ in 90mA Blocking: Blocking Solution:1X TBST with 5% w/v nonfat dry milk Time: 1h at room temperature Primary Antibody: Dilution: 0.5 µg/ml Diluent Buffer: 1X TBST with 5% BSA Incubation Time: overnight Incubation Temperature: 4℃ Washing Conditions: Wash Solution: 1X TBS-T (0.1% Tween-20) Time and Repetitions: 3 cycles for 5 minutes each Secondary Antibody Secondary :Anti-mouse IgG, HRP-linked Antibody Dilution: 1:5000 Diluent Buffer:0.1%Tween-20 TBS Incubation Time: 1h Incubation Temperature: at room temperature Developed using the ECL technique Exposure time : 2 minutes with Chemiluminescent Imager(Tanon 5200)
Date published: 2017-07-28
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MOZ 抗体 (4D8) is rated 4.7 out of 5 by 3.
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