Moxonidine hydrochloride CAS: 75438-57-2
MF: C9H12ClN5O•HCl
MW: 278.14
An Imidazoline receptor and an α2-adrenergic agonist.

Moxonidine hydrochloride (CAS 75438-57-2)

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Application: Moxonidine hydrochloride is an Imidazoline receptor and an α2-adrenergic agonist
CAS Number: 75438-57-2
Purity: ≥99%
Molecular Weight: 278.14
Molecular Formula: C9H12ClN5O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Moxonidine hydrochloride is a centrally acting antihypertensive agent. Mixed Nischarin (I1 imidazoline receptor) and α2-AR (adrenergic) agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors.


References

Schafer et al (2002) Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and a2-adrenoceptors. J.Pharmacol.Exp.Ther. 303 1163. El-Ayoubi et al (2004) Imidazoline receptors but not a2-adrenoceptors are regulated in spontaneously hypertensive rat heart by chronic moxonidine treatment. J.Pharmacol.Exp.Ther. 310 446. Chan et al (2005) Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience 132 991.

Physical State :
Solid
Solubility :
Soluble in ethanol (100 mM), and DMSO (100 mM).
Storage :
Desiccate at 4° C
Melting Point :
217-219° C
Boiling Point :
364.7° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Serotonin 1a (5-HT1a) receptor: IC50 = 702.1 nM (rat)
Ki Data :
Nischarin: Ki= 4.2 nM (human); Serotonin 1a (5-HT1a) receptor: Ki= 401.2 nM (rat); α2A-AR: Ki= 0.15 µM (human); α-2b adrenergic receptor: Ki= 1.00 µM (rat); α2C-AR: Ki= 2.00 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UV6260290
PubChem CID :
4810
MDL Number :
MFCD06795643
SMILES :
Cl.COC1=C(NC2=NCCN2)C(Cl)=NC(C)=N1

Download SDS (MSDS)

Certificate of Analysis

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