Molecular structure of Moxonidine hydrochloride, CAS Number: 75536-04-8
Moxonidine hydrochloride (CAS 75536-04-8)
Alternate Names:
MOXONIDINE HCl Moxonidine (hydrochloride) 5RYW07SK5E
Application:
Moxonidine hydrochloride is an Imidazoline receptor and an α2-adrenergic agonist
CAS Number:
75536-04-8
Purity:
≥99%
Molecular Weight:
278.14
Molecular Formula:
C9H12ClN5O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Moxonidine hydrochloride is a centrally acting antihypertensive agent. Mixed Nischarin (I1 imidazoline receptor) and α2-AR (adrenergic) agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors.
Moxonidine hydrochloride (CAS 75536-04-8) References
- Moxonidine reduces pilocarpine-induced salivation in rats. | Moreira, TS., et al. 2001. Auton Neurosci. 91: 32-6. PMID: 11515799
- Allosteric modulation of semicarbazide-sensitive amine oxidase activities in vitro by imidazoline receptor ligands. | Holt, A., et al. 2004. Br J Pharmacol. 143: 495-507. PMID: 15451775
- Receptors involved in moxonidine-stimulated atrial natriuretic peptide release from isolated normotensive rat hearts. | Mukaddam-Daher, S., et al. 2006. Eur J Pharmacol. 541: 73-9. PMID: 16774751
- Antihypertensive responses elicited by central moxonidine in rats: possible role of nitric oxide. | Moreira, TS., et al. 2006. J Cardiovasc Pharmacol. 47: 780-7. PMID: 16810079
- Potentiation by yohimbine of alpha-adrenoceptor-mediated vasoconstriction in response to clonidine in the rabbit ear vein. | Zhao, D., et al. 2008. Eur J Pharmacol. 589: 201-5. PMID: 18534573
- Evidence that some imidazoline derivatives inhibit peripherally the vasopressor sympathetic outflow in pithed rats. | Monroy-Ordoñez, EB., et al. 2008. Auton Neurosci. 143: 40-5. PMID: 18774761
- Pharmacological characterization of the inhibition by moxonidine and agmatine on the cardioaccelerator sympathetic outflow in pithed rats. | Cobos-Puc, LE., et al. 2009. Eur J Pharmacol. 616: 175-82. PMID: 19527708
- Imidazoline binding sites mediates anticompulsive-like effect of agmatine in marble-burying behavior in mice. | Dixit, MP., et al. 2014. Eur J Pharmacol. 732: 26-31. PMID: 24657463
- Investigation of the vasorelaxant effects of moxonidine and its relaxation mechanism on the human radial artery when used as a coronary bypass graft. | Sarac, B., et al. 2015. Interact Cardiovasc Thorac Surg. 21: 342-5. PMID: 26015507
- Pharmacological analysis of the cardiac sympatho-inhibitory actions of moxonidine and agmatine in pithed spontaneously hypertensive rats. | Cobos-Puc, LE., et al. 2016. Eur J Pharmacol. 791: 25-36. PMID: 27565220
- Pharmacological analysis of the inhibition produced by moxonidine and agmatine on the vasodepressor sensory CGRPergic outflow in pithed rats. | Rubio-Beltrán, E., et al. 2017. Eur J Pharmacol. 812: 97-103. PMID: 28694067
- Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. | Wang, C., et al. 2017. Stem Cell Reports. 9: 1221-1233. PMID: 28966121
Activator of:
AR, and Nischarin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Moxonidine hydrochloride, 10 mg | sc-204096 | 10 mg | $121.00 | |||
Moxonidine hydrochloride, 50 mg | sc-204096A | 50 mg | $495.00 |