Moxonidine hydrochloride is a centrally acting antihypertensive agent. Mixed Nischarin (I1 imidazoline receptor) and α2-AR (adrenergic) agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors.
Schafer et al (2002) Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and a2-adrenoceptors. J.Pharmacol.Exp.Ther. 303 1163. El-Ayoubi et al (2004) Imidazoline receptors but not a2-adrenoceptors are regulated in spontaneously hypertensive rat heart by chronic moxonidine treatment. J.Pharmacol.Exp.Ther. 310 446. Chan et al (2005) Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience 132 991.
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