Molecular structure of Moxifloxacin Hydrochloride, CAS Number: 186826-86-8
Moxifloxacin Hydrochloride (CAS 186826-86-8)
See product citations (18)
Alternate Names:
Actura; Avalox; Avelox
Application:
Moxifloxacin Hydrochloride is an antibacterial agent that inhibits the activities of Topo II (DNA gyrase) and topoisomerase IV
CAS Number:
186826-86-8
Purity:
≥99%
Molecular Weight:
437.89
Molecular Formula:
C21H24FN3O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Moxifloxacin hydrochloride provides a rich subject for bacteriological research. Scientists examine its bactericidal mechanism of action by studying its interaction with bacterial topoisomerases, which is pivotal for understanding how certain enzymes contribute to DNA replication and cell division. Its efficacy against a broad range of bacteria, including atypical pathogens, makes it a model compound for investigating bacterial resistance mechanisms, particularly the genetic mutations that confer resistance. Research in this area can help in the development of strategies to combat antibiotic resistance. Additionally, moxifloxacin hydrochloride is utilized in assays to determine the minimum inhibitory concentrations (MICs) for various bacterial strains, contributing to the fundamental knowledge of bacterial susceptibility.
Moxifloxacin Hydrochloride (CAS 186826-86-8) References
- Absolute bioavailability of moxifloxacin. | Ballow, C., et al. 1999. Clin Ther. 21: 513-22. PMID: 10321420
- Comparative in vitro and in vivo activity of the C-8 methoxy quinolone moxifloxacin and the C-8 chlorine quinolone BAY y 3118. | Dalhoff, A. 2001. Clin Infect Dis. 32 Suppl 1: S16-22. PMID: 11249824
- Penicillin-resistant streptococcus pneumoniae: review of moxifloxacin activity. | Dalhoff, A., et al. 2001. Clin Infect Dis. 32 Suppl 1: S22-9. PMID: 11249825
- Contribution of the 8-methoxy group to the activity of gatifloxacin against type II topoisomerases of Streptococcus pneumoniae. | Kishii, R., et al. 2003. Antimicrob Agents Chemother. 47: 77-81. PMID: 12499172
- Photodegradation of Moxifloxacin Hydrochloride Solutions under Visible Light Irradiation: Identification of Products and the Effect of pH on their Formation. | Zhou, J., et al. 2018. AAPS PharmSciTech. 19: 1182-1190. PMID: 29256152
- Fast dissolving moxifloxacin hydrochloride antibiotic drug from electrospun Eudragit L-100 nonwoven nanofibrous Mats. | Giram, PS., et al. 2018. Mater Sci Eng C Mater Biol Appl. 92: 526-539. PMID: 30184779
- Eudragit RL100 Based Moxifloxacin Hydrochloride and Ketorolac Tromethamine Combination Nanoparticulate System for Ocular Drug Delivery. | Salvi, V. and Pawar, P. 2020. Pharm Nanotechnol. 8: 133-147. PMID: 32167436
- Moxifloxacin Hydrochloride-Loaded Eudragit® RL 100 and Kollidon® SR Based Nanoparticles: Formulation, In vitro Characterization and Cytotoxicity. | Kırımlıoğlu, GY., et al. 2021. Comb Chem High Throughput Screen. 24: 328-341. PMID: 32342810
- Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Moxifloxacin Hydrochloride. | Charoo, NA., et al. 2020. J Pharm Sci. 109: 2654-2675. PMID: 32534881
- Development and optimization of hot-melt extruded moxifloxacin hydrochloride inserts, for ocular applications, using the design of experiments. | Thakkar, R., et al. 2021. Int J Pharm. 603: 120676. PMID: 33961956
- A rapid RP-HPLC stability-indicating method development and validation of moxifloxacin hydrochloride-related substances in finished dosage forms. | Vankalapati, KR., et al. 2021. Biomed Chromatogr. 35: e5192. PMID: 34110029
- Chitosan/β-glycerophosphate in situ forming thermo-sensitive hydrogel for improved ocular delivery of moxifloxacin hydrochloride. | Asfour, MH., et al. 2021. Eur J Pharm Sci. 167: 106041. PMID: 34655737
- Rational synthesis of rare-earth lanthanum molybdate covered reduced graphene oxide nanocomposites for the voltammetric detection of Moxifloxacin hydrochloride. | Akilarasan, M., et al. 2022. Bioelectrochemistry. 146: 108145. PMID: 35550254
- Simultaneous Determination of Moxifloxacin Hydrochloride and Dexamethasone Sodium Phosphate in Rabbit Ocular Tissues and Plasma by LC-MS/MS: Application for Pharmacokinetics Studies. | Zhao, X., et al. 2022. Molecules. 27: PMID: 36432035
- In vitro activity of BAY 12-8039, a new fluoroquinolone, against species representative of respiratory tract pathogens. | Souli, M., et al. 1998. Int J Antimicrob Agents. 10: 23-30. PMID: 9624540
Inhibitor of:
Topo, and Topo II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Moxifloxacin Hydrochloride, 100 mg | sc-205758 | 100 mg | $122.00 | |||
Moxifloxacin Hydrochloride, 500 mg | sc-205758A | 500 mg | $452.00 |