Moxidectin (CAS 113507-06-5)
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Moxidectin is a chemical compound that functions as a potent anthelmintic and insecticide. It acts by binding to glutamate-gated chloride channels in the nervous system of nematodes and arthropods, leading to an increase in the permeability of the cell membrane to chloride ions. This results in hyperpolarization of the nerve or muscle cells, leading to paralysis and death of the targeted parasites. Moxidectin′s mechanism of action involves disrupting the normal functioning of the nervous system in these organisms, ultimately leading to their demise. Moxidectin′s mechanism of action at the molecular level involves its specific interaction with glutamate-gated chloride channels, which are essential for the proper functioning of the nervous system in nematodes and arthropods. By targeting these channels, moxidectin effectively disrupts the normal physiological processes in the parasites, ultimately leading to their elimination.
Moxidectin (CAS 113507-06-5) References
- Analytical profile of moxidectin. | Awasthi, A., et al. 2013. Profiles Drug Subst Excip Relat Methodol. 38: 315-66. PMID: 23668407
- Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance. | Prichard, RK. and Geary, TG. 2019. Int J Parasitol Drugs Drug Resist. 10: 69-83. PMID: 31229910
- Omadacycline tosylate, Sarecycline hydrochloride, Rifamycin sodium, and Moxidectin. | Hussar, DA. and Chahine, EB. 2019. J Am Pharm Assoc (2003). 59: 756-760. PMID: 31522740
- Responsible use of moxidectin in sheep. | Hart, N. 2020. Vet Rec. 186: 161. PMID: 32029673
- Moxidectin: an oral treatment for human onchocerciasis. | Milton, P., et al. 2020. Expert Rev Anti Infect Ther. 18: 1067-1081. PMID: 32715787
- Characterization of Moxidectin against Strongyloides ratti: In Vitro and In Vivo Activity and Pharmacokinetics in the Rat Model. | Buchter, V., et al. 2021. ACS Infect Dis. 7: 1069-1076. PMID: 32991142
- Moxidectin: an ally to ivermectin for treating Strongyloides stercoralis? | Bisoffi, Z. and Buonfrate, D. 2021. Lancet Infect Dis. 21: 1060-1061. PMID: 33798488
- Moxidectin toxicity to zebrafish embryos: Bioaccumulation and biomarker responses. | Muniz, MS., et al. 2021. Environ Pollut. 283: 117096. PMID: 33866217
- Solvatomorphism of Moxidectin. | Grell, T., et al. 2021. Molecules. 26: PMID: 34443452
- Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells. | Dinesh Kumar, N., et al. 2022. Antimicrob Agents Chemother. 66: e0154321. PMID: 34633839
- Optimizing moxidectin dosing for Strongyloides stercoralis infections: Insights from pharmacometric modeling. | Hofmann, D., et al. 2022. Clin Transl Sci. 15: 700-708. PMID: 34889057
- Moxidectin: heartworm disease prevention in dogs in the face of emerging macrocyclic lactone resistance. | Savadelis, MD., et al. 2022. Parasit Vectors. 15: 82. PMID: 35277180
- Pharmacokinetics of oral moxidectin in individuals with Onchocerca volvulus infection. | Tan, B., et al. 2022. PLoS Negl Trop Dis. 16: e0010005. PMID: 35333880
- Moxidectin induces autophagy arrest in colorectal cancer. | Mao, Y., et al. 2022. Med Oncol. 39: 211. PMID: 36175702
- Ivermectin and moxidectin against soil-transmitted helminth infections. | Hürlimann, E., et al. 2023. Trends Parasitol. 39: 272-284. PMID: 36804383
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Moxidectin, 25 mg | sc-224098 | 25 mg | $109.00 |