Morin anhydrous CAS: 480-16-0
MF: C15H10O7
MW: 302.25
An antioxidant flavonoid.

Morin anhydrous (CAS 480-16-0)

Morin anhydrous | CAS 480-16-0 is rated 5.0 out of 5 by 1.
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Alternate Names: 2',3,4',5,7-Pentahydroxyflavone
Application: Morin anhydrous is an antioxidant flavonoid
CAS Number: 480-16-0
Purity: ≥85%
Molecular Weight: 302.25
Molecular Formula: C15H10O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Morin is an antioxidant flavonoid. Morin shows anti-proliferative and antitumor properties. Induces apoptosis. Induces cell cycle arrest at the G2/M phase. Anti-inflammatory compound. Suppresses NF-κB activation. Morin induces lipid peroxidation and DNA strand breaks. Morin is an inhibitor of Xanthine Oxidase.


References

1. Rice-Evans, C.A., et al. 1996. Free Radical Biol. Med. 20: 933-956. PMID: 8743980
2. Sahu, S.C. and Gray, G.C. 1997. Food Chem. Toxicol. 35: 443-447. PMID: 9216742
3. Kuo, H.M., et al. 2007. Anticancer Res. 27: 395-405. PMID: 17352259
4. Manna, S.K., et al. 2007. Clin. Cancer Res. 13: 2290-2297. PMID: 17404114

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol (50 mg/ml), water (0.25 mg/ml at 20° C), alcohol (freely), ether, and acetic acid.
Storage :
Store at room temperature
Melting Point :
299-300° C (dec.)
Boiling Point :
717.7° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.82 (Predicted)
IC50 :
Rat: IC50 = 0.12 µM; GPR35: IC50 = 1.60 µM (human); SLC22A12: IC50 = 2.00 µM (human); 3-oxoacyl-acyl-carrier protein reductase : IC50 = 2.3 µM (Plasmodium falciparum); Topo IIα: IC50 = 40.8 ug.mL-1 (human)
Ki Data :
SLC22A12: Ki= 5.74 µM (human); Adenosine A1 receptor: Ki= 13.8 µM (rat); Adenosine A2 receptors : Ki= 17.3 µM (rat); Adenosine A3-R: Ki= 34 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LK8749000
PubChem CID :
5281670
Merck Index :
14: 6269
MDL Number :
MFCD00217054
EC Number :
207-542-9
SMILES :
C1=CC(=C(C=C1O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Manna et al Manna et al. (PubMed ID 17404114) found that Morin anhydrous suppressed the carcinogen-induced activity of NF-kappaB, resulting in apoptosis and reduced cell proliferation. -SCBT Publication Review
Date published: 2015-04-15
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