MOPS is a morpholino propanesulfonic acid, a structural analog to MES, the ethanesulfonic acid (first introduced by Good et al.) Both series of buffers were developed to meet the following criteria: midrange pKa, maximum water solubility and minimum solubility in all other solvents, minimal salt effects, minimal change in pKa with temperature chemically and enzymatically stable, minimal absorption in visible or UV spectral range, and reasonably easily synthesized. pKa=7.2 at 25°C, Effective buffering range.
1. Good, N.E. et al. 1966. Biochemistry. 5(2): 467-477. PMID: 5942950
2. Thomas, J.M. and Hodes, M.E. 1981. Anal. Biochem. 118(1): 194-196. PMID: 6278979
3. Ellis, K.J. and Morrison, J.F. 1982. Meth. Enzymol. 87 : 405-426. PMID: 7176924
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