Montelukast-d6 (CAS 1093746-29-2)
CAS Number:
1093746-29-2
Molecular Weight:
592.22
Molecular Formula:
C35H30D6ClNO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Montelukast-d6, is the labeled analogue of Montelukast, a selective leukotriene D4-receptor antagonist. Montelukast-d6 can be used as an internal standard in mass spectrometry-based assays to accurately measure the kinetics of montelukast. The deuterated version helps in distinguishing the compound from its metabolites and quantifying it in biological samples without interference from the non-deuterated compound. It provides a tool for studying the metabolism of montelukast, as the presence of deuterium can influence the rate of metabolic reactions (kinetic isotope effect). This can offer insights into how the compound is processed in biological systems.
Montelukast-d6 (CAS 1093746-29-2) References
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- Method development and validation of montelukast in human plasma by HPLC coupled with ESI-MS/MS: application to a bioequivalence study. | Challa, BR., et al. 2010. Sci Pharm. 78: 411-22. PMID: 21179354
- Interchangeability and comparative effectiveness between generic and brand montelukast immediate release tablets after a single oral administration in healthy volunteers. | Zaid, AN., et al. 2015. Clin Transl Allergy. 5: 37. PMID: 26561521
- Novel montelukast sodium-loaded stable oral suspension bioequivalent to the commercial granules in rats. | Kim, DW., et al. 2016. Arch Pharm Res. 39: 539-546. PMID: 26983932
- A Review of Different Analytical Techniques for Fexofenadine Hydrochloride and Montelukast Sodium in Different Matrices. | Nalini, CN. and Kumar, V. 2021. Crit Rev Anal Chem. 51: 232-245. PMID: 31899949
- Comparative pharmacokinetics of a montelukast/levocetirizine fixed-dose combination chewable tablet versus individual administration of montelukast and levocetirizine after a single oral administration in healthy Korean male subjects . | Moon, SJ., et al. 2020. Int J Clin Pharmacol Ther. 58: 354-362. PMID: 32271144
- Pilot Study of Peak Plasma Concentration After High-Dose Oral Montelukast in Children With Acute Asthma Exacerbations. | Arnold, DH., et al. 2021. J Clin Pharmacol. 61: 360-367. PMID: 32960980
- A simple and sensitive HPLC-MS/MS assay for the quantitation of montelukast in cell-based systems in vitro pulmonary drug permeability study. | Wang, S., et al. 2021. J Pharm Biomed Anal. 192: 113657. PMID: 33053506
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Montelukast-d6, 1 mg | sc-477457 | 1 mg | $380.00 |