Molecular structure of Monosodium urate (crystals), CAS Number: 1198-77-2
Monosodium urate (crystals) (CAS 1198-77-2)
See product citations (5)
Alternate Names:
Uric acid monosodium salt (crystals)
Application:
Monosodium urate (crystals) is a Cryopyrin inflammatory compound that induces IL-1β production
CAS Number:
1198-77-2
Molecular Weight:
190.10
Molecular Formula:
C5H3N4O3•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Monosodium urate (crystals) has been reported to be an inflammatory compound. Mechanistic studies suggest that this compound intracellularly engages caspase-1-activating cryopyrin inflammasome, resulting in the production of active IL-1beta and IL-18. Experiments have shown that monosodium urate (crystals) also induce triggering receptor expressed on myeloid cells 1 (TREM-1) expression in infiltrating leukocytes in a murine air-pouch model of crystal-induced acute inflammation. Monosodium urate (crystals) is also an activator of cryopyrin.
Monosodium urate (crystals) (CAS 1198-77-2) References
- Safe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophages. | Landis, RC., et al. 2002. Arthritis Rheum. 46: 3026-33. PMID: 12428246
- Monosodium urate and calcium pyrophosphate dihydrate (CPPD) crystals, inflammation, and cellular signaling. | Liu-Bryan, R. and Lioté, F. 2005. Joint Bone Spine. 72: 295-302. PMID: 15990350
- Gout-associated uric acid crystals activate the NALP3 inflammasome. | Martinon, F., et al. 2006. Nature. 440: 237-41. PMID: 16407889
- Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals. | Murakami, Y., et al. 2006. Arthritis Rheum. 54: 455-62. PMID: 16447220
- MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. | Chen, CJ., et al. 2006. J Clin Invest. 116: 2262-71. PMID: 16886064
- Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals. | Scott, P., et al. 2006. J Immunol. 177: 6370-8. PMID: 17056568
- Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process. | Giamarellos-Bourboulis, EJ., et al. 2009. Ann Rheum Dis. 68: 273-8. PMID: 18390571
- Monosodium urate crystals in inflammation and immunity. | Shi, Y., et al. 2010. Immunol Rev. 233: 203-17. PMID: 20193001
- Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. | Hoffman, HM., et al. 2010. Arthritis Rheum. 62: 2170-9. PMID: 20506351
- Bonding the foe - NETting neutrophils immobilize the pro-inflammatory monosodium urate crystals. | Schorn, C., et al. 2012. Front Immunol. 3: 376. PMID: 23233855
- The crystallization of monosodium urate. | Martillo, MA., et al. 2014. Curr Rheumatol Rep. 16: 400. PMID: 24357445
- Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals. | Dalbeth, N., et al. 2015. Ann Rheum Dis. 74: 786-90. PMID: 25646371
- Targeting inflammatory mediators with ferulic acid, a dietary polyphenol, for the suppression of monosodium urate crystal-induced inflammation in rats. | Doss, HM., et al. 2016. Life Sci. 148: 201-10. PMID: 26851531
Activator of:
CARD 8, Cryopyrin, Macrophagee Marker, NAIP2, NAIP7, NALP1, NALP2, and NALP9.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Monosodium urate (crystals), 2 mg | sc-202711 | 2 mg | $155.00 |