Molecular structure of Monodesethyl Quinacrine, Dihydrochloride, CAS Number: 908844-46-2
Monodesethyl Quinacrine, Dihydrochloride (CAS 908844-46-2)
Alternate Names:
N4-(6-Chloro-2-methoxy-9-acridinyl)-N1-ethyl-1,4-pentanediamine
Application:
Monodesethyl Quinacrine, Dihydrochloride is a metabolite of Quinacrine, which is an antimalarial compound
CAS Number:
908844-46-2
Molecular Weight:
444.83
Molecular Formula:
C21H26ClN3O•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Monodesethyl Quinacrine, Dihydrochloride interacts with specific proteins in cells, affecting their function and ultimately leading to changes in cellular processes. It can bind to DNA, altering its structure and interfering with its replication and transcription. This can impact gene expression and protein production. It can disrupt the function of certain enzymes, affecting various metabolic pathways within the cell. It has the ability to modulate the activity of ion channels, influencing the flow of ions across cell membranes. These interactions can have downstream effects on cellular signaling and communication.
Monodesethyl Quinacrine, Dihydrochloride (CAS 908844-46-2) References
- Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. | Huang, Y., et al. 2006. Drug Metab Dispos. 34: 1136-44. PMID: 16581945
- DNA-damaging activity and mutagenicity of 16 newly synthesized thiazolo[5,4-a]acridine derivatives with high photo-inducible cytotoxicity. | Di Giorgio, C., et al. 2008. Mutat Res. 650: 104-14. PMID: 18160333
- Assessment of cation trapping by cellular acidic compartments. | Marceau, F., et al. 2014. Methods Enzymol. 534: 119-31. PMID: 24359951
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Monodesethyl Quinacrine, Dihydrochloride, 1 mg | sc-218871 | 1 mg | $475.00 |