Monocytes Marker Antibody (ER-HR3): sc-52706

Monocytes Marker Antibody (ER-HR3) is a rat monoclonal IgG2c antibody that detects Monocytes Marker protein of mouse origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Monocytes Marker (ER-HR3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Monocytes Marker protein plays a crucial role in the immune response, particularly in the identification and elimination of pathogens. Monocytes, which are derived from hematopoietic stem cells in the bone marrow, circulate in the bloodstream and migrate into tissues where they differentiate into macrophages. These cells are essential for phagocytosis, a process where they ingest and destroy foreign substances, utilizing intermediary proteins such as antibodies or complements that tag pathogens for destruction. Additionally, monocytes can directly bind to microbes through pattern-recognition receptors, enhancing their ability to respond to infections. The transition of monocytes into macrophages is vital for maintaining tissue homeostasis and initiating inflammatory responses, making Monocytes Marker protein an important target for studying immune system dynamics and related diseases, including atherosclerosis.

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Monocytes Marker Antibody (ER-HR3) References:

1. Macrophage marker 27E10 on human keratinocytes helps to differentiate discoid lupus erythematosus and Jessner's lymphocytic infiltration of the skin.  |  Kunz, M., et al. 1999. Eur J Dermatol. 9: 107-10. PMID: 10066957
2. Human osteoblast-like cells phagocytose metal particles and express the macrophage marker CD68 in vitro.  |  Heinemann, DE., et al. 2000. J Bone Joint Surg Br. 82: 283-9. PMID: 10755442
3. Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: insight into the timing and severity of injury in child abuse.  |  Berger, RP., et al. 2004. J Neurotrauma. 21: 1123-30. PMID: 15453983
4. [The 'classical' macrophage marker CD68 is strongly expressed in primary human fibroblasts].  |  Kunz-Schughart, LA., et al. 2003. Verh Dtsch Ges Pathol. 87: 215-23. PMID: 16888915
5. The leukaemic hairy cell in culture lacks the monocyte marker, angiotensin converting enzyme induction.  |  Silverstein, E., et al. 1988. Cytobios. 53: 57-62. PMID: 2833377
6. Alpha-naphthyl butyrate esterase (a selective cytochemical monocyte marker).  |  Lippi, U., et al. 1983. Ric Clin Lab. 13: 467-71. PMID: 6658305
7. Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins.  |  Holness, CL. and Simmons, DL. 1993. Blood. 81: 1607-13. PMID: 7680921
8. Immunophenotyping of dermal spindle cell tumors: diagnostic value of monocyte marker Ki-M1p and histogenetic considerations.  |  Rudolph, P., et al. 1997. Am J Surg Pathol. 21: 791-800. PMID: 9236835
9. An immunohistochemical study of IgG, complement C3, collagen type III and macrophage-marker Ki-M7 in epiretinal membranes.  |  Shi, Y., et al. 1996. Yan Ke Xue Bao. 12: 10-4. PMID: 9275730

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Monocytes Marker Antibody (ER-HR3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Monocytes Marker Antibody (ER-HR3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Monocytes Marker Antibody (ER-HR3) Specifications

Alternate Product Name: Monocytes Marker

Product Clone Name: ER-HR3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2c

Amino Acids:

Epitope Target: Monocytes Marker

Epitope Species: mouse

Product Reactivity/Detection: the majority of blood monocytes and a subset of mature resident macrophages (especially those located in hemopoietic organs)

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG_2c in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Monocytes Marker Antibody (ER-HR3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin