Molecular structure of Monoacylglycerol Lipase Inhibitor, URB602, CAS Number: 565460-15-3
Monoacylglycerol Lipase Inhibitor, URB602 (CAS 565460-15-3)
Alternate Names:
N-[1,1′-biphenyl]-3-yl-carbamic acid, cyclohexyl ester
Application:
Monoacylglycerol Lipase Inhibitor, URB602 is a cell-permeable N-biphenyl carbamate compound
CAS Number:
565460-15-3
Molecular Weight:
295.38
Molecular Formula:
C19H21NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
This product is a cell-permeable N-biphenyl carbamate compound that has been found to act as a non-competitive and selective monoacylglycerol lipase inhibitor. It has not been found to inhibit FAAH, COX-2, or diacylglycerol lipase activity. It has been shown to increase antinociception induced by stress, most likely through increasing 2-arachidonylglycerol levels.
Monoacylglycerol Lipase Inhibitor, URB602 (CAS 565460-15-3) References
- An endocannabinoid mechanism for stress-induced analgesia. | Hohmann, AG., et al. 2005. Nature. 435: 1108-12. PMID: 15973410
- Microglia produce and hydrolyze palmitoylethanolamide. | Muccioli, GG. and Stella, N. 2008. Neuropharmacology. 54: 16-22. PMID: 17631917
- The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation. | Comelli, F., et al. 2007. Br J Pharmacol. 152: 787-94. PMID: 17700715
- URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. | King, AR., et al. 2007. Chem Biol. 14: 1357-65. PMID: 18096504
- Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model. | Desroches, J., et al. 2008. Br J Pharmacol. 155: 913-24. PMID: 18695638
- Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate. | Nallapaneni, A., et al. 2008. Neurotoxicology. 29: 1037-43. PMID: 18765251
- Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. | Guindon, J., et al. 2011. Br J Pharmacol. 163: 1464-78. PMID: 21198549
- Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase. | Araki, M., et al. 2016. J Biochem. 160: 269-279. PMID: 27198176
- 2-Arachidonoylglycerol endocannabinoid signaling coupled to metabotropic glutamate receptor type-5 modulates anxiety-like behavior in the rat ventromedial prefrontal cortex. | Almeida-Santos, AF., et al. 2017. J Psychopharmacol. 31: 740-749. PMID: 28440729
- Monoacylglycerol Lipase Inactivation by Using URB602 Mitigates Myocardial Damage in a Rat Model of Cardiac Arrest. | Hai, K., et al. 2019. Crit Care Med. 47: e144-e151. PMID: 30431495
Inhibitor of:
Enzyme, FAAH, and Monoglyceride Lipase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Monoacylglycerol Lipase Inhibitor, URB602, 10 mg | sc-203141 | 10 mg | $170.00 | |||
Monoacylglycerol Lipase Inhibitor, URB602, 50 mg | sc-203141A | 50 mg | $550.00 |