Date published: 2026-1-9

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mono-Ethyl fumarate (CAS 2459-05-4)

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Alternate Names:
Fumaric acid monoethyl ester; Monoethyl fumarate
CAS Number:
2459-05-4
Molecular Weight:
144.13
Molecular Formula:
C6H8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Mono-Ethyl fumarate serves as an intermediate in the creation of diverse compounds and materials. It finds utility in various laboratory applications, acting as a catalyst, reagent, and inhibitor. As a catalyst, it aids in synthesizing a range of compounds, including polymers. Additionally, it functions as a reagent in organic synthesis and an inhibitor during the creation of organic compounds, while also serving as a solvent for organic substances.


mono-Ethyl fumarate (CAS 2459-05-4) References

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  2. Acylammonium salts as dienophiles in Diels-Alder/lactonization organocascades.  |  Abbasov, ME., et al. 2014. J Am Chem Soc. 136: 4492-5. PMID: 24588428
  3. Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives.  |  Lesma, G., et al. 2014. Beilstein J Org Chem. 10: 1383-9. PMID: 24991292
  4. Bacterial fumarase and L-malic acid are evolutionary ancient components of the DNA damage response.  |  Singer, E., et al. 2017. Elife. 6: PMID: 29140245
  5. Exploiting λ-Orthogonal Photoligation for Layered Surface Patterning.  |  Lederhose, P., et al. 2018. Chemistry. 24: 576-580. PMID: 29159967
  6. Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors.  |  Rajić, Z., et al. 2018. Molecules. 23: PMID: 30011922
  7. Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides.  |  Beus, M., et al. 2019. Acta Pharm. 69: 233-248. PMID: 31259728
  8. Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents.  |  Beus, M., et al. 2019. Molecules. 24: PMID: 31374989
  9. Ligand-Promoted RhI -Catalyzed C2-Selective C-H Alkenylation and Polyenylation of Imidazoles with Alkenyl Carboxylic Acids.  |  Zhao, H., et al. 2022. Chemistry. 28: e202200441. PMID: 35388545
  10. Depletion of Fumarate Hydratase, an Essential TCA Cycle Enzyme, Drives Proliferation in a Two-Step Model.  |  Solaimuthu, B., et al. 2022. Cancers (Basel). 14: PMID: 36428601
  11. Alcohol inhibits the metabolism of dimethyl fumarate to the active metabolite responsible for decreasing relapse frequency in the treatment of multiple sclerosis.  |  Yang, B., et al. 2022. PLoS One. 17: e0278111. PMID: 36441753
  12. Phytochemical Analysis and Toxicity Assessment of Bouea Macrophylla Yoghurt.  |  Rusli, RNM., et al. 2023. Toxins (Basel). 15: PMID: 36828439

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

mono-Ethyl fumarate, 25 g

sc-250415
25 g
$67.00